🚨 New framework alert!

Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬

From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯

#MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊

Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism.

He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind).

Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by refraining from beliefs, one could achieve tranquility.

His teachings laid the foundation for later skeptical thought in philosophy and medicine.

🧬 New hope for lipid warriors!

Solbinsiran (siRNA) slashed apoB 🩸, TGs 🍟, LDL-C 💔 & liver fat 🫀 in just 205 pts with mixed dyslipidaemia.

Safe ✅ Durable ✅ Quarterly dosing? Maybe ✅

Let's talk outcomes! 🎯

#PROLONGANG3 #RNAtherapy #CardioTwitter #LipidLowering

🧔‍♂️ Prostate cancer is the most common cancer in US men.

🧪 PSA testing? 🔍 It's all about shared decision-making.

🧬 From Gleason scores to PSMA-PET, precision reigns.

💉 ARPIs & ADT = survival gains in advanced disease.

⚖️ Screen smart. Treat right. Save lives.

#ProstateCancer #MensHealth #Oncology 🧠💪

🚨 New frontier in lipid-lowering!

🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50%

🛡️ Safe, well-tolerated, no lymph node issues

💡 Promising for residual ASCVD risk

Next step? Big trials, big answers! 📊🫀

#LipidScience #CardioTwitter #PrecisionMedicine

Why do some people sleep just 4 hours and feel great? 😴💪

A new study links the 🧬 SIK3-N783Y mutation to natural short sleep!

Less sleep, more delta power 🧠⚡

🚀🛌

#SleepScience #Genetics #SIK3 #ShortSleepers

🫀 Post-op AFib? Blame IL-6!

New @JClinInvest study shows IL-6 ➡️ STAT3 ➡️ CaMKII ➡️ RyR2 leak triggers post-op AFib.

🧬 Macrophage IL-6Rα is the match.

🧯 TTI-101 & KN-93 douse the flame.

⚡ Targeting IL-6 signaling = future Rx?

#CardioTwitter #AFib #Inflammation #JCI

🥦🍎 Want to age like fine wine? Choose high-quality carbs!

In a 32-year study of 47K women, fiber-rich carbs (from 🌾, 🥗, 🌱) boosted odds of healthy aging 🧠💪🧘‍♀️

Refined carbs? Not so kind.

#HealthyAging #NutritionMatters #WomensHealth 🧬📊💚

🧠🫀🧫 New study in Nature Medicine shows that multiorgan MRI predicts both 💔 cardiovascular and 🩸 liver events.

Cardiac (LVEF ≤50%) + Liver (cT1 ≥800ms) = 🚨 higher risk & earlier events.

Integrated imaging = smarter prevention! 🔍📊

#Cardiology #Hepatology #MRI #MASLD #CVD

🚀 New Breakthrough in Liver Cancer! 🌟

The CheckMate 9DW trial shows that Nivolumab + Ipilimumab significantly improves survival in unresectable #HCC compared to lenvatinib/sorafenib! 🧬💪

#Immunotherapy #CancerResearch #LiverCancer #Oncology 💉