🚨New COPD diagnosis alert!🫁

A multidimensional schema using CT 🖼️ + symptoms 😮‍💨 + spirometry 📉 identified high-risk patients missed by GOLD!

📈↑Mortality (HR 1.98)

📉FEV1 decline (–7.7 mL/y)

📊 Reclassified 15% w/o obstruction as COPD!

👉CT matters. #PulmTwitter #COPD #MedTwitter @doximity

🚨 New data! In the KARDIA-2 trial, 🧬 zilebesiran—an RNAi therapeutic—cut SBP by up to 12 mmHg when added to common antihypertensives

💊. One shot, 6 months of BP control!

📉 Promising for poor adherence.

Mild AEs. #Hypertension #Cardiology #RNAi 🌍【JAMA 2025】

🧬 Big win for longevity!

A Nature Aging study shows that combining 💊 trametinib + rapamycin extends lifespan, reduces tumors, and tames inflammation in mice 🐭🔥

Dual geroprotectors = additive benefits without added toxicity 🛡️🕰️

Future of anti-aging? Watch this space 👀

#Aging #Longevity #Geroprotectors #Science 🧪 @doximity

🧠💉 New Lancet study (OPTIMISTmain) shows low-intensity monitoring after thrombolysis in mild strokes may be just as safe as standard care!

💤 Less sleep disruption, 🧑‍⚕️ lighter nursing load, ⚖️ similar outcomes.

Could this change global stroke care? 🌍🏥

#Stroke #Thrombolysis #OPTIMISTmain #Neurology

🚨New A2B Trial in JAMA!

Can 🧪dexmedetomidine or clonidine beat 💉propofol in sedating ICU patients on ventilators?

❌ No faster extubation

⚠️ More bradycardia & agitation

⚖️ Similar mortality

Verdict: No clear winner—tailor sedation to patient needs 🛌👨‍⚕️

#CriticalCare #ICU #SedationTrial

🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery!

💉 Faster reperfusion

📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%)

⚠️ Slight ↑ in sICH, but no major safety red flags

🧪 #BRIDGE_TNK trial rewrites the stroke playbook!

#Stroke #Tenecteplase #NeuroTwitter

Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism.

His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rejecting inherent existence.

Nāgārjuna's philosophy has profoundly influenced Mahāyāna thought and continues to shape Buddhist studies and practice today.

📢 New RCT in Nature Medicine 🎯

Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI?

🔬 SUPPRESS-AF Trial

👥 342 pts with persistent AF

📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI)

❌ Not statistically significant

🧠 Subgroup benefit in high-risk pts

#EPeeps #AFib #CardioTwitter 🫀

🧠💪 Can blood biomarkers of Alzheimer's predict who'll lose muscle strength with age?

In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset.

🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #Longevity

📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023:

🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID

🦠 But plateaued post-pandemic at 6.0 hrs/day

🚶‍♀️ Progress stalled—time to get moving again!

#PublicHealth #NHANES #PhysicalActivity 🏃‍♂️📊🛋️