Dr RR Baliga's "Got Knowledge Doc" Podkast

🚨 New in 2025! The ACC/AHA Appropriate Use Criteria for ICDs, CRT, and Pacing just got a major upgrade! 🫀📊 Covering 335 real-world scenarios, this document is your go-to guide for when (and when not) to implant. 💡

What's 🔥 in the update?

⚡ Leadless & conduction system pacing

🔁 CRT refined for better outcomes

🧠 Smart use in LVADs, post-transplant, & more

👩‍⚕️ Clinicians: Make device decisions with clarity, confidence, and evidence.

📥 Download our podcast + slides to stay ahead.

#Cardiology #ICD #CRT #Pacing #AUC #HeartFailure #EP #PrecisionMedicine #MedEd #2025Guidelines

🧘‍♂️📿 Discover the timeless wisdom of Adi Shankaracharya (788–820 CE) — the master of Advaita Vedanta who redefined spirituality with concepts like Atman, Brahman & Sanyasa. His teachings on non-duality still inspire seekers worldwide. 🌍📚 #Philosophy #Vedanta #Spirituality

🫀 New insights from Covani et al. and Ben-Yehuda's editorial reveal a striking paradox: more cardiovascular risk factors 🔥 = more plaque rupture, but less erosion! 🧊

Using OCT imaging, they show how traditional risks drive inflammatory, rupture-prone plaques, while erosion may follow a different path altogether—less lipid, less inflammation, more mystery. 🧬

🎯 Takeaway: Precision prevention must evolve. Not all plaques (or patients) follow the same script.

🔗 Dive into this convergence of epidemiology & imaging 👉 #PlaqueVulnerability #STEMI #NSTEMI #OCT #Cardiology #Prevention #PrecisionMedicine

🌍🔬 What's shaping your health beyond your genes?

Introducing our latest Got Knowledge Doc podcast episode: "Beyond Genes, Beneath the Skin 🧬🌫️" — a deep dive into the exposome, the totality of your environmental exposures from womb to tomb.

From microplastics to sleep, PFAS to social stress, we're mapping the missing link in precision medicine.

🎧 Tune in to explore why the future of health might depend less on your DNA and more on your data trail.

🧠 Prevention. 📊 Policy. 💊 Personalization.

#Exposome #PrecisionMedicine #EnvironmentalHealth #PublicHealth #WearableTech #GotKnowledgeDoc

🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓

Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️

From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉

🧠 A must-read for cardiologists, immunologists & translational researchers!

📄 Wang et al., Sci. Transl. Med. 2025

🔗 #Cardiology #HCM #TREG #Immunotherapy #Fibrosis #PrecisionMedicine #TranslationalScience #HeartFailure #IL2 #CellTherapy

🧠💤 Just dropped our latest Got Knowledge Doc podcast:

"Flush, Sleep, Forget: The Glymphatic Code in Alzheimer's Disease" 🧬🎧

We explore how the brain's nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it's a story of sleep, science, and hope. 🌙🔬

Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer's. 🧪🧩

#AlzheimersDisease #GlymphaticSystem #Neuroscience #SleepScience #BrainHealth #AQP4 #CognitiveDecline #PrecisionMedicine #Neuroimaging #MedicalPodcast 🎙️

🚨 New Podcast Episode!

🎙️ "Gut Talks to the Heart 🥗💓🧠: The Incretin Connection"

Did you know that GLP-1 and GIP do far more than control blood sugar?

These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline.

💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism.

🔗 Tune in to learn how your next meal could be triggering an endocrine symphony.

#Cardiology #Endocrinology #Incretins #GLP1 #GIP #Metabolism #Neuroprotection #DiabetesCare #PrecisionMedicine #MedicalPodcast 🎧

Exciting new insights from Science Translational Medicine (2025)!

Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉

💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa.

💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues.

This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨

#RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq #Biotech #Innovation #TranslationalScience

☕💓 Is your daily brew helping or harming your heart?

New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1–4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality.

🧬 Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles.

⚠️ But beware: excessive intake and unfiltered brews may raise LDL.

📊 Great read for clinicians navigating patient questions on coffee and cardiovascular risk.

🔗 #Coffee #Cardiology #CME #HeartHealth #LifestyleMedicine #PreventiveCardiology #EvidenceBasedMedicine

🧠🧬 New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity.

A youthful brain and immune system cut mortality risk nearly in half—more so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine.

📊 Machine learning + blood proteins = next-gen aging biomarkers.

🔗 Study link: https://doi.org/10.1038/s41591-025-03798-1

#Longevity #Proteomics #BrainHealth #ImmuneSystem #Aging #Biomarkers #PrecisionMedicine #UKBiobank #HealthyAging #Neuroimmunology #PlasmaProteomics #OrganAging