In the 1970s, a pair of brothers and their longtime friend begin smuggling cocaine from their home city of Cali, Colombia into the United States. They quickly establish a complex but highly efficient system for importing and distributing vast quantities of the drug, creating what becomes known as the Cali Cartel. Laundering their money through legitimate businesses in Colombia, the men from Cali become extremely wealthy. Soon, other budding entrepreneurs in Colombia take notice. The most ambitious among them is a young man named Pablo Escobar. He wants his organization, based out of Medellin, Colombia, to surpass the Cali Cartel as the biggest importer of cocaine into the United States.

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