The series features an ensemble cast led by Lance Reddick as the clones of Albert Wesker, Ella Balinska and Adeline Rudolph as Wesker's adopted children, Tamara Smart and Siena Agudong portrays the daughters' younger selves, and Paola Núñez as James Marcus's daughter Evelyn. It alternates between two timelines, following Jade and Billie Wesker during their days in New Raccoon City where they discover their father's and Umbrella Corporation's dark secrets, and 14 years in the future, where Jade tries to survive the end of the world.