The 49ers' home opener against the Arizona Cardinals brought plenty of twists and turns as San Francisco emerged victorious to maintain its undefeated start with a thrilling 16-15 win. Kicker Eddy Piñeiro's game-winning field goal and Mac Jones' clinical two-minute drive got the 49ers over the hump in a gutsy win, improving San Francisco to 3-0 in the 2025 season. The win didn't come without its costs as star defensive end Nick Bosa exited the game with an apparent knee injury. Matt Maiocco and Jennifer Lee Chan break down the 49ers' courageous victory, Bosa's injury and how San Francisco's alleged weakness in depth has turned into their strength as they now sit atop the NFC West standings.

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(1:00) Uncommon scoreline, but 49ers are making these kinds of win common
(3:00) Nick Bosa injury update
(6:00) Eddy Piñeiro delivers in the clutch
(10:00) Mac Jones seems to rise to the occasion
(12:00) 49ers' defense is putting the team on their back
(30:00) Robert Saleh has been the key to unlocking 49ers' defense

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