ENT Update

ENT Update Podcast - 2026/05/21 (週四：睡眠醫學專題)

討論主題：睡眠呼吸中止症最新治療選擇

重點整理：

1. AD109 口服藥 Phase 3 SynAIRgy 成功 — AHI下降55.6%，已送FDA (AJRCCM, May 18 2026)

2. Zepbound (tirzepatide) 首個FDA核准用於肥胖型OSA藥物

3. Inspire V 雙側舌下神經刺激器 — 新一代植入裝置

4. Barbed Suture Pharyngoplasty — 倒刺縫線咽喉整形術

5. Solriamfetol — 改善OSA白天嗜睡

製作：洪士涵醫師

ENT Update, Episode 39 | 2026/05/20. ENT Head and Neck Medicine latest information.

ENT Update Podcast - 2026/05/19 (週二：耳科與聽力學專題)

討論文獻：

1. Otarmeni(lunsotogene parvec) FDA Accelerated Approval - First gene therapy for OTOF hearing loss (Apr 23, 2026)

2. Envoy Medical Acclaim Fully Implanted CI - 56 patients activated (Apr 2026)

3. Osia 2 System Audiological Outcomes - Otol Neurotol (Mar 1, 2026)

4. Polygenic SNHL GWAS - Million Veteran Program, JARO (Mar 16, 2026)

本期 ENT Update Podcast（2026/5/18 週一）探討頭頸外科與腫瘤學專題。主持人傅醫師與林醫師辯證式討論以下文獻：

KEYNOTE-689 圍手術期 Pembrolizumab 用於局部晚期頭頸癌

- NEJM 2025; DOI: 10.1056/NEJMoa2501065

- FDA 已核准用於可切除局部晚期 HNSCC 圍手術期治療

NIVOPOSTOP (GORTEC 2018-01) — 輔助性 Nivolumab 用於高風險頭頸癌

- Lancet 2026; DOI: 10.1016/S0140-6736(25)02713-7

- 3年無疾病存活率 63.1% vs 52.5%（HR 0.76）

TORS 長期腫瘤學預後 — HPV 陽性口咽癌五年存活率接近 90%

- Otolaryngol Head Neck Surg 2026

TORS 單一治療吞嚥功能長期追蹤

- Head & Neck 2026

SEOM-TTCC 2025 頭頸癌治療指引更新

- Clin Transl Oncol 2026

CSCO 2026 頭頸部腫瘤診療指南

ENT Update 2026-05-18 頭頸部腫瘤特輯

參考文獻:

1. Lactylation-driven metabolic-immune crosstalk: CD44, APP causal risk genes in HNSCC. Front Immunol, 15 May 2026. DOI: 10.3389/fimmu.2026.xxxxx

2. Neural-derived CCL5-Treg-RAMP1 axis: perineural invasion causes immunosuppression. J Immunother Cancer, 8 May 2026. DOI: 10.1136/jitc-2026.xxxxx

3. EGFR/Cyclin D1/Bcl-2 high expression prognostic meta-analysis. OTO Open, 14 Apr 2026. DOI: 10.1002/oto2.xxxxx

4. LEAP-010: Pembro+Lenvatinib improves PFS but not OS in R/M HNSCC. JCO, Mar 2026. DOI: 10.1200/JCO.2026.xxxxx

5. PNI predicts poor Pembrolizumab efficacy. Laryngoscope, Jan 2026. DOI: 10.1002/lary.xxxxx

6. SLC16A1/MCT1-STAT3-SLC7A11 ferroptosis axis. Oncol Res, 2026. DOI: 10.32604/or.2026.xxxxx

7. Future of systemic therapy for R/M HNSCC: bispecific Abs & HPV vaccines. Front Oncol, 26 Mar 2026. DOI: 10.3389/fonc.2026.xxxxx

8. Personalized medicine: ctDNA de-escalation, risk-adapted CRT. Front Oncol, 15 May 2026. DOI: 10.3389/fonc.2026.xxxxx

9. Anterior skull base ACC: GTR + proton therapy optimal. Eur J Cancer, May 2026. DOI: 10.1016/j.ejca.2026.xxxxx

10. PROMs quality of life clinical application. Qual Life Res, May 2026. DOI: 10.1007/s11136-026-xxxxx

ENT Update Podcast - 2026年5月17日 (一週專題回顧)

參考文獻：

1. SEOM-TTCC HNC guidelines. Clin Transl Oncol. 2026 Mar 17.

2. NIVOPOST-OP. Lancet. 2026 Jan 24.

3. Neoadjuvant chemoimmunotherapy HNC. PMID: 41842604

4. CI in Asymmetric Hearing Loss. Otol Neurotol. 2026 Mar.

5. Biologics CRSwNP. PMID: 41518424

6. THN3 pHGNS 3yr. Chest 2026 May. DOI: 10.1016/j.chest.2025.11.057

7. OSPREY pHGNS. Annals Intern Med. 2026 Apr 20.

8. Hydrogel vocal cord. Biomaterials. McGill. 2026.

9. OBIL UVFP. PMID: 41353483

10. AI CADx Laryngoscopy. OTO HNS. 2026 Feb. DOI: 10.1002/ohn.70153

11. DL scoping OHNS. Nature Digital Med. 2025.

12. DL model ENT. Sci Rep. 2026 Feb 10.

睡眠外科特輯｜PPPP｜OSA+LPR｜舌骨懸吊｜pHGNS 3年｜HNS分期｜OSPREY｜機器人舌根｜術前篩檢｜唐氏症兒童｜ENT Update Podcast

ENT Update Podcast - 2026/05/16

主題：人工智慧在耳鼻喉科應用

本集討論文獻：

1. Integration of AI into ENT practice: comparative study

Egypt J Otolaryngol (2026 Mar 23)

DOI: 10.1186/s43163-026-01055-x

URL: https://link.springer.com/article/10.1186/s43163-026-01055-x

2. Generative AI in otolaryngology (Kowalski et al.)

Otorhinolaryngol 2026;76(1):23-35

DOI: 10.23736/S2724-6302.26.02601-0

3. ML prediction of eosinophilic CRSwNP

PMID: 41847830 (2026 Mar 18)

URL: https://pubmed.ncbi.nlm.nih.gov/41847830/

ENT Update Podcast - 2026/05/15 - 喉科學與聲音醫學

References:

1. AAO-HNS/ASHA Consensus Statement on the Use of Voice Therapy in the Treatment of Dysphonia (2026 Mar 3). https://www.entnet.org/resource/consensus-statement-on-the-use-of-voice-therapy-in-the-treatment-of-dysphonia/

2. Treatment Efficacy for Functional Voice Disorders with Dysphonia: A Network Meta-analysis. Journal of Voice (2026 Mar 3). https://www.sciencedirect.com/science/article/pii/S0892199726000676

3. Intralesional Steroid Injection vs Voice Therapy for Early Vocal Fold Nodules: An RCT. European Archives of Oto-Rhino-Laryngology (2025 Dec 29). https://link.springer.com/article/10.1007/s00405-025-09923-7

4. Outcomes of Voice Therapy in Organic Voice Disorders: A Scoping Review. Journal of Voice (2026 May 5). https://www.sciencedirect.com/science/article/pii/S0892199726001335

5. Long-Term Retention of Voice Therapy Outcomes After Discharge. Journal of Voice (2025 Dec 18). PubMed: 41419425

6. Clinical Applications of Laryngeal Ultrasonography: A Review. Journal of Voice (2025 Oct 29). PubMed: 41168021

7. Family-Involved Hybrid Voice Therapy for Pediatric VF Nodules. Laryngoscope Investigative Otolaryngology (2026 Apr 30). https://onlinelibrary.wiley.com/doi/full/10.1002/lio2.70422

8. Barriers and Readiness to Voice Therapy Among School Teachers. Journal of Voice (2025 Jul 29).

ENT Update Podcast - 2026年5月14日 (週四)

主題：睡眠醫學

本集參考文獻：

1. Tirzepatide on OSA-related cardiometabolic risk: SURMOUNT-OSA secondary analysis

Nature Medicine, January 2026

DOI: 10.1038/s41591-025-04071-1

https://www.nature.com/articles/s41591-025-04071-1

2. Proximal hypoglossal nerve stimulation for OSA: A randomized controlled trial

The Lancet Respiratory Medicine, April 2026

https://medicalxpress.com/news/2026-04-implanted-nerve-obstructive-apnea-safe.html

3. SleepFM: AI model predicts disease risk from sleep data

Nature Medicine / Stanford Medicine, January 2026

https://med.stanford.edu/news/all-news/2026/01/ai-sleep-disease.html

4. Mayo Clinic AI-enabled ECG analysis for OSA detection

AASM Key Trends in Sleep Medicine Q1 2026

https://aasm.org/key-trends-in-sleep-medicine-q1-2026/

5. Growth and sleep outcomes after adenotonsillectomy in pediatric OSA

Scientific Reports, December 2025

DOI: 10.1038/s41598-025-30271-3

https://www.nature.com/articles/s41598-025-30271-3

6. Long-term Health Outcomes of Pediatric OSA

Sleep Medicine, May 2026

https://www.sciencedirect.com/science/article/abs/pii/S1389945726002480

7. Pediatric DISE-directed surgery outcomes in OSA

Otolaryngology-Head and Neck Surgery, February 2026

DOI: 10.1002/ohn.70166

https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/ohn.70166

主持人：傅醫師 (zh-TW-YunJheNeural) 與 林醫師 (zh-TW-HsiaoChenNeural)

語速：+12%