Dr. Josef Penninger is the Director of the Life Sciences Institute at the University of British Columbia and a Canada 150 Chair in Functional Genetics. He was previously the Scientific and Founding Director of the Institute for Molecular Biotechnology of the Austrian Academy of Sciences. His research is focused on understanding the complex mechanisms of how diseases develop, particularly in cardiovascular, autoimmune and bone diseases, and cancers.

Shutting Down Glioblastoma at its Earliest Moments – By performing cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer, scientists have identified a molecular driver of glioblastoma.

The Bone Marrow Microenvironment at Single-Cell Resolution –  Researchers have mapped the transcriptional landscape of mouse bone marrow cell populations, both at homeostasis and under conditions of stress-induced hematopoiesis.

Exploring the Mouse Gut Endoderm at Single Cell Resolution – Investigators have shown that throughout embryogenesis endoderm cells acquire a transcriptional identity that reflects their future fate and spatial positioning.

Specification of Positional Identity in the Forebain – Scientists have grown topographically organized human forebrain organoids using engineered signaling centers.

The Developmental Origin and Lifespan of Osteoclasts – Researchers have identified the developmental origin of osteoclasts and a mechanism that controls their maintenance in bones after birth.

Photo Reference: Courtesy of Dr. Josef Penninger

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