Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem cells, and applying this information to generate tissue-specific stem/progenitor cells endowed with in vivo regenerative potential. Much of her work is focused on muscular dystrophies.

New CAR T-Cell Therapy Less Toxic – A Phase I clinical trial has shown that a redesigned CAR T-cell molecule was less toxic and produced fewer side effects in patients, making the treatment safer.

Using MSCs to Engineer an HSC Niche – Researchers have identified genes in mesenchymal stem cells that enhanced the production of niche factors that could maintain hematopoietic stem cells in culture.

Generating Ovarian Cancer Organoids – Investigators developed a protocol for generating and expanding ovarian cancer organoids, and demonstrated their potential applications.

Stress-Resistant Muscle Stem Cells – Scientists have identified a population of muscle stem cells that resist radiation and are able to expand under severe stress.

Muscle Stem Cells Protected from Environmental Stress – The expression of a transcription factor has been shown to protect muscle stem cells against environmental stress caused by a toxic pollutant.

Photo Reference: Courtesy of Dr. Rita Perlingeiro

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