Dr. Karl Koehler is an Assistant Professor of Otolaryngology at Harvard Medical School. His lab develops organoid systems to study human sensory organ development and function, and to model congenital diseases and develop regenerative medicine therapies for the inner ear and various craniofacial tissues.

Variable Outcomes in Neural Differentiation – Investigators have found that the variability in outcomes during in vitro differentiation of human PSCs to neural lineage cells is due to differences in a developmental signaling pathway.

Human Embryo-Like Model Created from Human Stem Cells – A new model has been developed to study gastrulation in early development using human ESC-derived gastruloids.

Boosting Natural Killer Cell Activity with iPSCs – Using iPSCs and deleting a key gene, scientists have created natural killer cells with an enhanced ability to inhibit leukemic cells, both in vivo and in vitro.

Brain Organoids that Predict Drug Permeability – Researchers have generated human central nervous system organoids with a barrier that is selective to small molecules, and that secrete cerebrospinal fluid.

Photo Reference: Courtesy of Dr. Karl Koehler

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