Dr. Samira Musah is an Assistant Professor in the Department of Biomedical Engineering and Associate Professor in Medicine at Duke University. The Musah lab applies stem cell biology to engineer functional models of the human kidney and brain, with the goal of developing novel therapeutic models for human kidney diseases and understanding the mechanisms of neurodegeneration in patients with chronic kidney disease and other pathological conditions.

Promoting Cardiac Repair after Injury – Investigators have found that lymphoangiocrine signals promote cardiac growth, repair and cardioprotection in mice — a process that is mediated by the extracellular protein reelin.

Restoring Sight by Rewinding the Epigenetic Clock – Inducing the expression of three Yamanaka transcription factors in mouse retinal ganglion cells restored youthful DNA methylation patterns, promoted axon regeneration after injury, and reversed vision loss.

Mesenchymal Stromal Cells Drive Fibrosis – Scientists have identified two bone marrow mesenchymal stromal cell subsets that drive fibrosis and progression of myeloproliferative neoplasms. They identified a drug that inhibits the mechanism involved.

New Tool for Cell Engineering– A comprehensive library of human transcription factors has been created that enables systematic investigation of transcription factor-based programming for cell engineering.

Photo Reference: Courtesy of Dr. Samira Musah

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