Dr. Jürgen Knoblich is Scientific Director of the Institute of Molecular Biotechnology at the Austrian Academy of Sciences. The Knoblich lab is known for the development of an organoid model of early brain development, and is currently using iPSCs and cerebral organoids to investigate inter-brain region interactions, neurodevelopmental disorders, and neuronal connections and functions.

Study Reveals Immune Driver of Brain Aging – Researchers have identified a key factor in mental aging, and suggested that it might be prevented or reversed by reprogramming myeloid glucose metabolism.

A Tonsil Organoid System for Studying Adaptive Immunity – Scientists have developed a tonsil organoid system, and used it to evaluate immune responses to rabies and SARS-CoV-2 vaccines.

Antisense Oligonucleotide Targets IRF4 Gene to Treat Multiple Myeloma – Researchers have shown that silencing IRF4 with an antisense oligonucleotide impairs myeloma cell survival and promotes sensitivity to clinical drugs.

Illuminating the Path to Cervical Cancers – By creating novel organoid models, scientists have established a new approach to studying the biology of the cervix, and have identified key turning points in cancer development.

Photo Reference: Courtesy of Dr. Jürgen Knoblich

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