Dr. Krishanu Saha is an Associate Professor in the Department of Biomedical Engineering at the University of Wisconsin-Madison. His lab utilizes quantitative and bioengineering methods including genome editing, biomanufacturing, and disease modeling to advance the next generation of cell and gene therapies.

Growing Advanced Embryos Outside the Uterus – Researchers removed mouse embryos from the uterus at five days of gestation and grew them for six more days in roller culture systems, allowing them to reach advanced organogenesis.

Lacrimal Gland Organoids That “Cry” – Scientists established long-term 3D organoid cultures of human and mouse lacrimal glands and used neurotransmitters to induce tear secretion.

Generating Human “Blastoids” – Starting with either human ESCs or iPSCs, researchers used a three-dimensional culture strategy to generate blastocyst-like structures in vitro.

Reprogramming Fibroblasts into iBlastoids – Fibroblasts were reprogrammed in vitro into three-dimensional models of the human blastocyst, termed iBlastoids.

SARS-CoV-2-Induced Cardiac Damage in iPSC-Derived Heart Cells  – Scientists infected iPSC-derived cardiac cells with SARS-CoV-2 to better understand how the virus attacks the heart.

Cytokine Storms in Cardiac Organoids – Using SARS-CoV-2-infected cardiac organoids and mice, researchers found that bromodomain and extraterminal domain family inhibition reduced infection and cardiac damage.

Photo Reference: Courtesy of Dr. Krishanu Saha

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