Dr. Ilyas Singeç is the Director of the Stem Cell Translation Laboratory at the National Center for Advancing Translational Sciences, where he leads a group of scientists working to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies. He discusses the standardization of stem cell differentiation, high-throughput cell culture, personalized medicine, and the potential for biomanufacturing in space.

Blastoid Implantation in Endometrial Organoids – Scientists generated blastoids, performed single-cell analysis of the trophectoderm, epiblast, and primitive endoderm, and implanted them into open-faced endometrial organoids.

Pancreatic Progenitor Implants for Type 1 Diabetes – Pancreatic endoderm cells implanted in patients with type 1 diabetes were well-tolerated and induced meal-regulated insulin secretion.

YAP Signaling in Dry Mouth – Stimulating YAP activity promotes regeneration of mouse and human salivary gland cells after injury.

Cardiac and Gut Tissues in Multilineage Organoids – Scientists developed a human multilineage iPSC-derived organoid that recapitulates cooperative cardiac and gut development and maturation.

Photo Reference: Courtesy of Dr. Ilyas Singeç

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