Dr. Clive Svendsen is the Executive Director of the Regenerative Medicine Institute at Cedars-Sinai. His lab uses stem cells to develop models and treatments for neurodegenerative diseases. He talks about using stem cells to model spinal muscular atrophy and the blood-brain barrier, and his cell-gene therapy trial for ALS.

Embryonic Angiogenesis – Monocytes deposit migrasomes to promote angiogenesis in chick embryos.

Stem Cell Crosstalk with the Microenvironment – Ras drives malignancy in squamous cell carcinoma through aberrant crosstalk between cancer stem cells and their microenvironment.

The Extracellular Matrix and Naive Pluripotency – A three-dimensional extracellular matrix-rich environment preserves long-term feeder-free naive hiPSC self-renewal.

Cell Senescence in Alzheimer’s Disease – Alzheimer’s disease brains have high proportions of neurons that express senescence markers.

Photo Reference: Courtesy of Dr. Clive Svendsen

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