Dr. Sebastian Diecke is a Group Leader and Stem Cell Core Director at the Max Delbrück Center, where his research focuses on iPSCs and organoid models. He talks about the early days of iPSC research, developing organoids from endangered rhinoceros, and modeling Huntington’s and other diseases.

Blood Self-Renewal – Researchers identified a crucial regulator that modulates endocytosis and environmental sensing in hematopoietic stem cells.

Cardiomyocytes After Heart Attack – iPSC-derived cardiomyocytes were successfully engrafted into two rhesus macaques with small, subclinical chronic myocardial infarctions.

CHIP and Gum Disease – DNMT3A-driven clonal hematopoiesis of indeterminate potential (CHIP) and inflammatory bone loss are reversed by rapamycin.

Turtle Liver Organoids – Scientists developed and characterized adult stem cell-derived turtle liver organoids.

Image courtesy of Dr. Sebastian Diecke

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