Dr. Ludovic Vallier is the W3 Einstein Strategic Professor for Stem Cells in Regenerative Therapies at the Berlin Institute of Health and a Max Planck Fellow at the Max Planck Institute for Molecular Genetics. His lab uses stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy. He talks about modeling non-alcoholic fatty liver disease and his lab’s pivot to SARS-CoV-2 research early in the pandemic. He also discusses how iPSCs could be used to regenerate the liver after injury.

Enhancing Compatibility in Interspecies Chimeras – Researchers used nanobody-antigen interactions to increase the chimerism of human PSCs in mouse embryos.

Single-Nucleotide RNA Sequencing for Brain Aging – Scientists uncovered different cellular trajectories and cell communities in Alzheimer’s disease and normal aging.

Glial Cells in Multiple Sclerosis – iPSC-derived multiple sclerosis models provide a unique platform for dissecting glial contributions to disease phenotypes.

Organoids to Model Spinal Trigeminal Nucleus Development – Scientists differentiated hPSCs into region-specific brain organoids.

Image courtesy of Dr. Ludovic Vallier

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