Dr. Dmitriy Sheyn is an Associate Professor in the Department of Orthopedics and Regenerative Medicine Institute at Cedars-Sinai Medical Center. His lab focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. He talks about ways to model disc degeneration and tendon injuries. He also discuses his lab’s work on tendon differentiation and the mechanisms of low back pain.

Skin Transparency for Live Imaging – Researchers used tartrazine to make the skin of a live rodent temporarily transparent.

Muscle Regeneration – Scientists generated satellite cells from skeletal muscle tissue and transplanted them into mouse muscle.

Cardiac Assembloids – Scientists used PSC-derived cardiac assembloids to model the atrioventricular conduction axis and study complex disorders affecting heart rhythm.

Yamanaka Factors and Cellular Senescence – Partial cellular reprogramming improved health markers in mouse models of aging.

Image courtesy of Dr. Dmitriy Sheyn

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