Dr. Margaret “Peggy” Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. She also discusses the rich research environment in Houston. (42:41)

Human Fetal Ventral Mesencephalic Transplantation – Patients with Parkinson’s disease treated with fetal tissue were assessed three years after surgery. (1:48)

Mechanosensing Inhibition for Cardiac Fibrosis – Researchers identified a dual-drug strategy to combat cardiac fibrosis by targeting fibroblast mechanosensing pathways. (14:26)

Patterning of Brain Organoids – Orthogonal WNTs/SHH gradients pattern organoids into forebrain, midbrain, and hindbrain. (26:11)

Hepatocyte Organoid Expansion – Combined activation of Wnt and STAT3 signaling enables long-term self-renewal of human adult hepatocyte organoids. (34:22)

Image courtesy of Dr. Margaret Goodell

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