Dr. Thomas Vierbuchen is Assistant Professor of Developmental Biology at Memorial Sloan Kettering Cancer Center. In this episode, he talks about using PSCs to model neurodevelopmental processes. He also discusses his direct reprogramming work and his lab’s recent study on OTX2 in gastrulation. (42:02)

Restoring Function After Spinal Cord Injury: In a non-human primate model of spinal injury, researchers grafted ESC-derived spinal cord neural stem cells and improved forelimb function. (2:00)

Improving HSC Expansion: Inhibiting ferroptosis augments the expansion of HSCs ex vivo. (11:40)

Cardiomyocytes and Macrophage Reprogramming: Injury-induced Clusterin+ cardiomyocytes promote neonatal heart regeneration by reprogramming macrophages. (21:27)

Bone Marrow Organoids: A 3D in vitro bone marrow model captures phenotypic, structural, and functional features of human endosteal bone marrow niches. (33:03)

Image courtesy of Dr. Thomas Vierbuchen

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