In this eye-opening episode, Daniela and Buzz sit down in person with Buckeye PMRs Joe Matovich to break down the real science behind the wildly popular weight loss drug Semaglutide—and the risks most physicians conveniently leave out of the conversation.

Joe explains what GLP-1 drugs like Semaglutide actually are, how they work on a hormonal level (hint: it’s way more than just appetite suppression), and why your gut microbiome might be the missing piece in how your body naturally regulates weight and glucose.

We get into:

• What GLP-1 (Glucagon-Like Peptide-1) actually is and what it does in the body

• How Semaglutide impacts insulin, glucagon, satiety, and gastric motility

• The overlooked role of gut bacteria like Akkermansia, Faecalibacterium, and Roseburia in GLP-1 production

• The potential long-term consequences of using GLP-1 drugs that aren’t making headlines

Whether you're considering Semaglutide or just curious about the latest in metabolic health, this episode brings a refreshing dose of nuance, research, and real-talk.