Stop Feeling Like Shit Podcast

EP 84: 40% of People Have This Gene Mutation (MTHFR Explained)


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In this episode, we’re breaking down one of the most misunderstood genetic topics in wellness: the MTHFR gene mutation and what it actually means for your health.

Did you know that up to 40% of the global population carries a variant of the MTHFR gene? We dive into the two most common mutations — C677T and A1298C — and how they can impact methylation, homocysteine levels, cardiovascular health, energy, and mood.

We also unpack:

  • What methylation actually is (and why it matters)

  • How MTHFR affects your body’s ability to process folate

  • The connection between elevated homocysteine and heart health

  • Why synthetic folic acid may not be ideal for everyone

  • The critical role of B vitamins as methylation co-factors

  • Symptoms commonly associated with impaired methylation

  • How to get tested (blood test, genetic testing, organic acid testing)

If you’ve struggled with fatigue, brain fog, anxiety, cardiovascular concerns, or unexplained health issues, this episode will help you better understand whether methylation and MTHFR could be part of the picture.

As always, we focus on practical, empowering information — not fear-based genetics.

Listen now and take the next step toward understanding your body better.

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Stop Feeling Like Shit PodcastBy Dr. Roy Korth and Daniela Korth

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