Ablate before you radiate. Success with bone tumor ablation may have as much to do with your procedure technique as it does with your ability to collaborate. In this episode of BackTable MSK, interventional oncologist Dr. Damian Dupuy shares his approach to bone tumor ablation with host Dr. Kavi Krishnasamy, and offers practical advice on how to partner with your cancer care team to make ablation a viable treatment option.

---

This podcast is supported by:

Medtronic Osteocool

https://www.medtronic.com/en-us/healthcare-professionals/products/surgical-energy/ablation/radiofrequency-ablation/systems/osteocool-2-0-bone-tumor-ablation-system.html

---

SYNPOSIS

The doctors review the history of bone ablation techniques, including radiofrequency and cryoablation modalities. They discuss the significance of targeting the bone-tumor interface for pain palliation and highlight several case studies to illustrate various techniques and successful outcomes. The conversation also touches upon the synergistic benefits of combining ablation with radiation therapy and emphasizes the importance of multidisciplinary collaboration in treating cancer patients.

---

TIMESTAMPS

00:00 - Introduction
02:07 - Dr. Dupuy’s Start in Bone Ablation
06:29 - Cryo vs. Microwave Therapies
08:25 - Dr. Dupuy’s Clinical Trial and Research Involvement
12:49 - Patient Selection and Treatment Strategies
25:54 - Sedation and Anesthesia Practices in Bone Ablation
28:46 - Treatment Approach: Oligometastases vs. Progressive Disease
36:22 - Microwave Ablation in Bone: Future Prospects
37:30 - Techniques for Treating Sclerotic and Lytic Lesions
40:01 - Skin Protection Methods in Superficial Lesion Treatments
41:49 - Reviewing Recent Clinical Trials: MOTION, OPuS One, and More
52:35 - Case Studies: Achieving Effective Ablation Techniques
01:08:08 - Final Thoughts and Recommendations

---

RESOURCES

Dr. Damian E. Dupuy, MD, FACR
https://www.linkedin.com/in/damian-e-dupuy-md-facr-6b080b1b/

Solitary painful osseous metastases: correlation of imaging features with pain palliation after radiofrequency ablation--a multicenter american college of radiology imaging network study
https://pubmed.ncbi.nlm.nih.gov/23657892/

Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC10156864/

Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC8011449/

A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated with Percutaneous Ablation and Palliative Radiation Therapy (TRIBUTE)
https://clinicaltrials.gov/study/NCT06859801