This episode of the Pharm So Hard podcast discusses the use of clinical pharmacy practitioners in the emergency room and their impact on sepsis antibiotic interventions author by Aubrie Hammond, Regan Porter, Taylor Cason, et al. The study found that the involvement of EMCPPs significantly improved the selection and timing of antibiotic administration in septic patients. The pharmacist-driven protocol improved the rate of appropriate antibiotic selection from 57% to 86% and reduced the time to administration by 64 minutes. The study also highlighted areas where antibiotic selection could be further improved, such as UTIs and intra-abdominal infections. The role of pharmacists in optimizing treatment time and expanding the pharmacist-driven sepsis management model was also discussed.