This week, primary care physicians Kate Rowland, Mark Ebell, and Henry Barry want to arm our primary care colleagues with the best evidence on whether acetaminophen causes autism, whether MMR causes autism, and whether leucovorin can treat autism. Gary then turns to a study of the value of continuity in primary care, and its association with better health outcomes.

Links:

Henry's essay on Ignaz Semelweis, handwashing, and postage stamps: https://thestampforum.boards.net/thread/13044/current-issue-volume-jul-2025

Essential Evidence Plus and POEMs: www.essentialevidenceplus.com

Acetaminophen in pregnancy and autism: https://www.ncbi.nlm.nih.gov/pubmed/38592388

Leucovorin to treat autism: https://www.ncbi.nlm.nih.gov/pubmed/15781839, https://www.ncbi.nlm.nih.gov/pubmed/34834493

MMR and autism, Wakefield investigation: https://www.bmj.com/content/342/bmj.c5347

MMR and autism, Madsen's Danish study: https://pubmed.ncbi.nlm.nih.gov/12421889/

Value of primary care continuity: https://www.ncbi.nlm.nih.gov/pubmed/40355250

And do NOT eat roadkill. Definitely.