You know them by their trade names such as Ozempic, Wegovy, Mounjaro, and Zepbound. This class of medications is known as GLP-1 receptor agonists. And while they are best known for managing diabetes and promoting weight loss, researchers are finding that these drugs are also effective in a broad range of other health conditions. So, what about MS?

My guest this week is Dr. Ellen Mowry, the principal investigator of a clinical trial to determine whether a GLP-1 drug can reduce brain inflammation and provide neuroprotection in people living with progressive MS.

We're sharing details about the discovery of a new biomarker that not only confirms an MS diagnosis but also predicts the severity of an individual's disease course in the years ahead.

We'll tell you about three studies focused on better managing some of the most common MS symptoms and funded by the International Progressive MS Alliance.

And we'll explain how Merck and the Mayo Clinic are partnering to build a first-of-its-kind drug discovery platform using AI.

We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: A GLP-1 for MS? :22

I'm asking for your support: 1:31

Researchers discover biomarkers that can predict future disease course 2:13

The International Progressive MS Alliance invests $8.1 million in global studies that address the most common MS symptoms 5:44

Merck and the Mayo Clinic collaborate on AI-driven drug discovery platform 10:02

Dr. Ellen Mowry discusses the clinical trial to determine whether a GLP-1 drug can reduce inflammation in the central nervous system and offer neuroprotection to people with progressive MS 12:20

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Next week 30:38

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STUDY: Large-Scale Proteomics Across Neurological Disorders Uncovers Biomarker Panel and Targets in Multiple Sclerosis https://pubmed.ncbi.nlm.nih.gov/41747728

International Progressive MS Alliance https://progressivemsalliance.org

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RealTalk MS Episode 444 Guests: Dr. Ellen Mowry

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