What are hyperreflective foci, and why do they matter in AMD? Prof. Stella Vujosevic is joined by Prof. Christine Curcio (University of Alabama at Birmingham) and Prof. Srinivas Sadda (Doheny Eye Institute, UCLA) to explore their significance—from donor eye histology to OCT imaging. They discuss key biomarkers, clinical implications, and how HRF can help guide treatment decisions in age-related macular degeneration