Kirsten Ostherr (Rice University) joins Merle and Lee to discuss the role of the humanities in the context of Covid, in particular in an applied sense. The interview begins with an overview of Kirsten’s project and a few examples of current work in the applied humanities that attempts to address Covid. Kirsten notes how her background has helped her reconsider and reframe the traditional roles of the humanities in this context, and continues to highlight some of the limits and challenges the humanities must face in the 21st century mediascape. She also comments on some ideas to increase the humanities outreach among specific and more receptive audiences.