US futures are pointing to a flat open as of 04:45 ET. European equity markets have opened lower, following broad weakness in Asian markets. Market narrative highlighted bond market reactions to Fed Chair Powell's comments with 10y yield just short of 5% at a 16-year high and the 2y notably lower. On the Israel-Hamas conflict, concerns of broader regional escalation heightening on reports IDF has been given the green light to move into Gaza and a drone attack on a US military base in southern Syria.

Companies Mentioned: CVC Capital Partners, Jazz Pharmaceuticals