In recent years, people are increasingly blaming perimenopause for a constellation of symptoms: weight gain, hair loss, brain fog. But does the evidence support this point of view? Who’s profiting from it? And what does it mean for perimenopause to be such a hot topic?

On this episode of the “First Opinion Podcast,” host Torie Bosch speaks with Patricia Bencivenga and Adriane Fugh-Berman of the Georgetown University Medical Center’s Pharmed Out project about their research on menopause and perimenopause, and why they’re concerned about women being too quick to blame their hormones.

“Women have been seen as erratic and unstable due to their hormone changes and their hormones for hundreds of years, right? You’re erratic, and untrustworthy when you’re pubescent, and then again your hormones are out of control when you’re PMSing, and then again, when you were having your period or you’re on the rag, or then again when you are pregnant, or then when you postpartum, or now perimenopausal or menopausal. So at what point are we going to be seen as fully stable and secure people?” said Bencivenga.

In 2023, Netflix released a documentary titled “Live to 100: Secrets of the Blue Zones,” which looked at some small, geographically isolated places around the world in which, reportedly, residents regularly lived to 100 or beyond.

It was just the most recent installment to a longevity franchise that began roughly 25 years ago. But how real are “blue zones”? And has the concept’s commercialization drowned out its scientific value?

Medical journalist Shelley Wood, author of the novel “The Leap Year Gene of Kit McKinley,” and cardiologist Eric Topol, author of “Super Agers,” recently teamed up recently to write a First Opinion essay examining blue zones at 25 years. They join host Tori Bosch on this episode of the “First Opinion Podcast” to discuss their findings and how the idea of blue zones fits into the current longevity craze. They argue that the concept, which originated with mountain villages in Sardinia, Italy, may have been flawed from the start, given how many records were destroyed by World War II — but that it still promotes some valuable ideas, especially in an age of longevity pseudoscience.

His real name is Will Flanary, but you probably know him as Dr. Glaucomflecken — the internet’s go-to doctor/comedian. On this episode of the “First Opinion Podcast,” we talked about how he mixes humor with some of the most pressing issues facing health care, from misinformation on social media to the corporate takeover of medicine.

In particular, Flanary has been deeply involved with advocacy around PeaceHealth’s decision to use a corporate group to staff the emergency department in Eugene, Oregon, instead of the community-based physicians who had been there for more than 35 years.

“There's a lot people in hospital administration, in health insurance, in private equity, doing bad things for patients and for doctors. And one unifying characteristic of every story … is that they don't want people to know what's happening. They want to keep it out of the news,” he told me. “They don't want this kind of scrutiny because they know this is really unpopular and that maybe this isn't the best for patient care, but it's maybe good for pocketbooks, maybe good for other reasons that are not as altruistic.” By “making a stink” on social media, he said, he hopes he can bring scrutiny to those trying to avoid it.

One of health secretary Robert F. Kennedy’s refrains has focused on medical education: Doctors don’t know enough about nutrition and preventive medicine, he likes to say. He has encouraged medical schools to beef up (tallow up?) their education on healthy eating and its connection to chronic disease.

What do medical students think of this?

On this week’s episode of the “First Opinion Podcast,” host Torie Bosch spoke with Tiffany Onyejiaka, a fourth-year medical student, and Lauren Rice, who is poised to start her residency in internal medicine this summer. Both have written First Opinion essays on Kennedy’s claims. In November, Tiffany argued that it would be more productive to support the work of registered dietitians and encourage them to collaborate with doctors. More recently, Lauren wrote that she agreed that medical school needs more of a preventive health mindset.

I brought them together to discuss each other’s arguments and compare their experiences in medical school.

“Our country's health is going down a very poor trajectory and something needs to change,” Lauren said on the podcast. “I don't have the answer to what that needs to be. I don't think Robert F. Kennedy Jr. has the answer. I don't think anyone has the answers. But the conversation needs to start and it needs to a conversation with a lot people at the table.”

Have you ever wondered how many drugs are behind the counter at your local pharmacy?

According to Thomas Goetz — a journalist, entrepreneur, and host of the new podcast “Drug Story” —  “there are over 3,000 drugs behind a typical pharmacist counter.” And behind each drug is a story.

On “Drug Story,” which debuted in January, Goetz picks one drug and examines its history, the disease it treats, and how it intersects with society and public health. “In every drug, every medication, there is a much larger story to tell about health and medicine and society and business and economics,” he told me on this episode of the “First Opinion Podcast.”

We talked about Ambien, Ozempic, and how drugs attempt to treat the ways modern life is incompatible with the human body; how his thinking about weight loss drugs has changed over the years; and much more — including my ill-fated attempts to feed a baby salmon puree to stave off fish allergies.

The deep distrust between public health and the Make America Healthy Again movement may seem impossible to heal. But the podcast “Why Should I Trust You?” is trying to do just that by facilitating conversation between people who often view each others as enemies.

Brinda Adhikari and Tom W. Johnson launched “Why Should I Trust You?” in 2025. Since then, they’ve hosted big names from MAHA, the Trump administration, the anti-vaccine movement, and traditional health. They also bring on everyday Americans trying to keep their families healthy while navigating a confusing information ecosystem. “Everyone, when they come on the show, no matter what their quote unquote, expertise, they're all equals. Everyone gets time to speak,” Adhikari said.

On this episode of the “First Opinion Podcast,” host Torie Bosch speaks with Adhikari and Johnson about their show’s goals and the criticism they’ve received from public health and MAHA alike.

Ahead of Monday’s NCAA men’s basketball final, much of the news coverage focused on two overlapping dynamics: 1) what bets to make and 2) how the rise of sports betting is causing damage.

According to Isaac Rose-Berman, a fellow at the American Institute for Boys and Men, the skyrocketing popularity of sports betting is a burgeoning public health crisis, especially for young men.

While men and women are roughly equally represented at the casino, with “sports betting you’re talking, you know, 85-90% of the users” are men, according to Isaac.

That results in two problems from a public health perspective: the financial cost, which can lead to depression, anxiety, and even suicide, and the compulsive behavior that pulls people out of their normal lives.

Religion and science can often seem in opposition, at least culturally. But they don’t have to be, say Marc Siegel and Francis Collins.

Siegel, who is a physician and a senior medical analyst at Fox News, has recently published a new book, “The Miracles Among Us: How God's Grace Plays a Role in Healing,” in which he tells stories of unexpected — miraculous, he says —recoveries.

On this episode of the “First Opinion Podcast,” host Torie Bosch speaks with Siegel and Francis Collins — former director of the National Institutes of Health and the author of “The Language of God: A Scientist Presents Evidence for Belief.” They discuss the intersection of faith and science, particularly the ways that some Christian communities have increasingly become skeptical of medicine like vaccines.

When Jason Karlawish started working with dementia patients in the late ’90s, there often wasn’t much he could offer them. “I gave them a diagnosis,” he told me on this week’s episode of the “First Opinion Podcast,” but had limited medications to prescribe. Now Karlawish — who is STAT’s Neurotransmissions columnist; a professor of medicine, medical ethics, health policy, and neurology at the University of Pennsylvania; co-director of the Penn Memory Center; and executive producer of the “Age of Aging” podcast — says a revolution is taking place in dementia care, thanks to diagnostics that are removing uncertainty and treatments that actually have some effect.

Celena Lozano's son Benny, who turned 5 in November, loves trains, trucks — anything that goes. He also has a rare disease, PURA syndrome.

Earlier this year, when headlines announced that a child with a different rare disease, known as Baby KJ, had been treated using CRISPR in a major breakthrough, Celena, a neuroscience Ph.D. candidate, found that many in the PURA community had major questions, with comments like “This happened in just six months. When will this be available for our PURA kids?” appearing on Facebook groups.

Celena and STAT reporter Jason Mast joined the podcast to discuss why CRISPR for PURA syndrome is particularly difficult, what it’s like to be both a rare disease parent and a scientist, and how crucial parents are to research.