The Victorian Government will today announce details around how it plans to manage COVID-19 cases as it rushes to vaccinate as many people as possible.

Yesterday, Premier Daniel Andrews said he'd be meeting with health officials to develop thresholds for the easing of the lockdown, where possible.

It's a move away from the COVID-zero goal of the past, as it appears unlikely that the state will manage to eliminate the spread of the Delta variant.

So on today's Coronacast, is this a new medium term strategy of balancing caseloads with the hope enough people will be vaccinated before the health system crumbles?

Also on today's show:

* Is there any research on having a mRNA shot first followed by Astra in terms of efficacy and safety?

* An interesting study on COVID-19 and immune-mediated inflammatory diseases