Naked Jane owner Kadri Gedelec has a lot to say about CBD and the unique process his company Naked Jane uses to distinguish themselves above and beyond the plethora of competitors who have jumped on the CBD oil trend bandwagon. Kadri recognizes not all CBD is created equal and uses a seven step process to create only the worlds highest quality of CBD oil. Make sure you check out why Naked Jane's process is unique and why their benefits outweigh their competition, even if that competition now offers their CBD in hamburger form. Naked Jane CBD oilEverything You Wanted to Know About CBD Oilby Jim GoetzColts Neck, NJAllow me to clarify that we are not poteads, stoners or what you could consider, "druggies". We never were.I (Jim Goetz), personally grew up a "normal" kid, playing with my blocks, He-Man and Teenage Mutant Ninja Turtles and ran around outside until my mom had to come find me and drag me in for dinner.When I met Chantea in college, I was a clean cut college baseball player with a huge substance abuse problem. I ate copious amounts of pecan pie, took large amounts of creatine (until I burped poweder), and drank large amounts of protein shake and water. I guess other than the pecan pie (something I had never been exposed to living in the Northeast all my life up until that point), these so called "problems" were typical of any jock and most likely still are. Until recently, the closest thing I have come to what would be considered a "substance" is utilizing nootropics for school, work and training such as nicotine and adrafinil along with melatonin and L-theanine. My mushrooms come in the form of chaga and lions mane. Of course the nootropics made by Alexander and Stefan of Nooflux are awesome! If you have not heard this podcast check out the show notes and take a gander after you are done here. You may already know or have done it yourself but many now are experimenting with edible tetrahydrocannabinol (THC) for exercise performance, and also experimenting with vaporizing indica-rich strains of marijuana for creativity, relaxation and sleep. In these show notes and podcast, we delve into a derivative of the cannabis plant family that is now being used as an infusion into a fast food burger. It has some pretty massive payoffs for balancing your endocrine system, relieving anxiety, modulating chronic stress, shutting down inflammation and chronic pain, decreasing blood sugar, decreasing appetite and lowering abdominal obesity.Sit back, grab your favorite nootropic and learn about a form of cannabis with zero psychoactive effects of weed but gives you all of the good stuff you want.
Cannabis 101When you hear someone discuss the topic of marijuana, typically they are referring to THC. This is the part of the plant (known as a hemp plant), that induces a state of euphoria. Some may enjoy this state while others find it annoying. Some however, believe it makes certain movies and cartoons, such as the entire Adult Swim, more than simply mildly palpable.The THC content is what the majority of recreational marijuana users desire. Back in the 1960's, bontanists were able to increase the amount of THC in marijuana (weed) from 3% to 5% to a whopping 28%, which is the amount typically found in the plant today. Back in the 60's, individuals would find a mild euphoric state as compared to today, which that same individual would find themselves inebriated on their ass.THC is a chemical compound that fits into a receptor already found in your body from birth called, CB1. This CB1 receptor is located in the cerebral cortex (brain). Fill too many receptors (intake a crapton of THC) and you will find yourself on your couch all day.There are currently 85 active cannabinoids identified in cannabis. One of which is called, Cannabidiol (CBD). This accounts for 40% of a plants total cannabinoid content.Whether you have seen the South Park episode where everyone becomes weed farmers or not; in these hemp fields, cannabis plants grow in a manner that the male plants are able to fertilize the female plants. When the male plants are quarantined from the female plants, they are no longer able to fertilize them. When females cannot be pollinated, they produce copious amounts of THC. When a female is happily fertilized, she only produces less than 1% THC. I am sure there is some joke that can be associated with this but I will let it go for now and leave it up to you the reader to come up with something good.Production of CBD (international standards require less than 1% THC), is dependent on good relations between the male and female cannabis plants.
Chemistry, Biochemistry, Organic Chemistry and Inoragnic Chemistry???I have been asked why would you want to take CBD without the fun of THC? other than being concerned about progress of your day and appearing as a coherent professional, there are a crapton of reasons why.But first, let us get into the text book stuff so you can understand the physiology of your body and what CBD’e effects truly are.As previously discussed, THC attaches primarily to CB1 receptors. CBD however, has a low affinity for both CB1 and CB2 receptors and acts as an indirect antagonist of the agonist. This means that what activates CB1 or CB2 are turned off by CBD.An example of this is CBD can increasing CB1 receptor density so that there’s too many CB1 receptors for THC to bind to, thus taking the edge off the potential psychoactivity of weed, while still retaining all the opioid-like painkilling effects.This means you have to increase the consumption of THC if you are using CBD separately. It also means that CBD will prolong the duration of effects of THC in your system as it inhibits cytochrome P-450. This enzyme causes the rapid metabolism of THC. As it is inhibited, the THC lasts longer and therefore you feel the effects longer.In using CBD, plasma concentrations of THC increase, causing increased amounts of THC to be available to CB1 receptors. With the increase, CBD acts as an antagonist at a cannabinoid receptor named GPR55, located in the caudate nucleus of the putamen (brain). This reduces the effects of THC. What this boils down to is by using CBD on it’s own, THC lasts longer but reduces any psychoactive effects. An actual receptor CBD effects is called 5-HT1A. This is why CBD has anti-depressant and anti-anxiety effects and is neuroprotective. It is also an “allosteric modulator” of opioid receptors, which is why it reduces pain and chronic inflammation.CBD was found to eliminate memory loss problems from marijuana (agonist/ antagonist relationship). CBD has really strong anti-oxidant and anti-inflammatory properties, due primarily to its effects on your adenosine receptors and cytochrome P-450 and 2C enzymes.Research has shown as with weed that includes THC, it is not possible to overdose on CBD. CBD has an unusually low level of toxicity. In over 6,000 years, not one individual has overdosed on pure CBD.Did you know:-NSAIDS (ibuprofen, Advil, Tylenol, and aspirin) kill over 1,000 people per year?-Alcohol kills over 110,000 people each year?-marijuana kills 0 people each year. Nada. Not one.CBD and AddictionThe reason CBD is not addictive is because CBD does not act on any receptors in your brain that produce an addiction. We discussed this previously...remember?Former national administrator of the US governments marijuana research programs, Dr. Tod Mikriya stated, “no other single drug or substance has as many therapeutic benefits as cannabis”. Dr. Mikriya never found or discussed any evidence of addiction to cannabis. I hear all the time though individuals state that cannabis is addictive. I hear all the time cannabis is a gateway drug and the federal government even locks people away for decades because of canabis. The Boggs Act of 1951 established mandatory sentences for drug users and stated that cannabis was addictive and has held it’s effect despite what other government officials and researchers such as Dr. Mikriya have discovered. Even Dr. Harris Isbell the Director of Research at the Public Health Service Hospital located in Lexington, Kentucky have villified the idea that cannabidols are not physically addictive. Oriental medicine has been used for over 6,000 years and used cannabis as a popular remedy. There have been no reported cases of addiction. The research study, Ganja in Jamaica: A Medical Anthropological Study of Chronic Marijuana Use, which was published in the Journal of the American Medical Association in 1975, disclosed zero concerns with addiction, even after patients who had used cannabis for decades had stopped. The 1980 study Cannabis in Costa Rica: A Study in Chronic Marijuana Use backed this up. Most interestingly, studies like this are not finding any addictive potential with CBD even in the presence of THC.Cannabis SafetyFor over 40 years, Dr. Lester Grinspoon, Professor Emeritus at Harvard Medical School, spent the majority of his professional life studying cannabis. The result was “Marijuana: The Forbidden Medicine“. As you can see, Dr. Grinspoon didn’t find one single case of death, stating, “There are no deaths from cannabis use. Anywhere. You can’t find one.”Francis Young, an administrative DEA judge, took medical testimony for over two weeks, and at the end of it, he said, “Marijuana, in its natural form, is one of the safest therapeutically active substances known to man.”In proper doses, CBD may produce the same pain reduction compared to opioid prescription drugs, such as morphine, hydrocodone, and oxycodone, and when combined with these drugs, allows you to use far less of the actual prescription, thus reducing the toxic load on your liver and kidneys.CBD and Your HormonesYour choice at this point is to stop reading, read a bunch of journal articles and do your own peer reviews, read a bunch of opinions online and at your local grocery store, or keep reading…...good...glad you are still here.Your endocrine system consists of glands throughout your body which regulates literally every function in your body from metabolism to sex and so forth. One function of your hormones is that in response to the fight or flight response. When your sympathetic system is activated, you produce excess cortisol levels. However, when cortisol levels continue to rise, you feel exhausted at all times and your performance decreases. CBD decreases plasma cortisol levels and as a result, can increase your performance and quality of life. But CBD has other effects on your endocrine system, particularly your appetite. You may simply think that marijuana produces the munchies and therefore makes you fat, and although this makes logical sense, science has shown that it’s not the case that marijuana makes you fat, especially when CBD is present.The idea behind smoking weed is that you get the munchies afterwards and as a result- gain weight. The opposite is true though. CBD stabilizes insulin, regulates your appetite and decreases cortisol. These are all aspects of weight gain/ loss. But it is actually the THC that increases your appetite. On the flip side, CBD can suppress your appetite. Hmmm….Physiologically speaking, your pancreas secretes the hormones glucagon and insulin to regulate blood sugar by signaling your liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. While THC primarily increases glucagon and blood sugar, CBD lowers insulin levels, and it is this CBD action that helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and have lower rates of type II diabetes than non-users, and is also why some diabetics find that marijuana makes it easier to manage their blood sugar.Type II diabetics (whose pancreas still functions) tend to have very high levels of insulin, but the liver is unable to use that insulin, so blood sugar stays high, and the pancreas eventually damages itself by trying to continually produce more and more insulin, eventually leading to organ failure if the diabetes is unmanaged. By lowering pancreatic insulin release, CBD may alleviate or prevent the progression of type II diabetes and blood sugar disorders. Cannabinoid antagonists such as CBD have been shown to reduce obesity, and not only do rodents given these antagonists eat less, but they also lose more weight than their reduced feeding can account for.So the summary of the biggest effects of CBD on the endocrine system? Lower cortisol and better blood sugar control. Yep...Your Anxiety and Stress and CBDWe discussed the effects of CBD and cortisol. When it comes to the full plant, it is THC that causes stress and anxiety unless there is enough CBD present in order to negate the effects. (recall the agonist/ antagonist relationship). This is due to CBD’s direct action on your 5HT1A and TRPV1 receptors (responsible for anxiolytic response to stress).Effective dosing appears to fall within the ranges from 10 mg to 100 mg, depending on the individual and the situation and even time of day. This is far healthier than the alternatives of addictive drugs such as Valium or Xanax. CBD and Your SleepIt is believed that in the United States, approximately 70 million people suffer from insomnia, insufficient sleep or another sleep disorder. It’s ironic that Cannabidiol actually activates the adenosine receptors as does caffeine, a stimulant. It has been found though that CBD has a calming effect that research shows allows people to sleep.You can use larger amounts of CBD to help drift blissfully to sleep (ex. 100 mg) or use smaller amounts and combine it with melatonin, lemon balm, valerian root, magnesium, chamomile or your favorite bedtime relaxation herb.CBD and InflammationInflammation is all the rage now-a-days, isn’t it? The answer to pre-mature aging and chronic disease is inflammation. It’s not really a rage or the trend but the truth. Low level inflammation is the enemy and easily caused by our faced paced, high stress lives with great amounts of pollution in our environment and pro-inflammatory foods that are consumed.Let’s nerd out for a moment. Signaling proteins called, cytokines are synthesized and secreted by your immune cells (macrophages, T-lymphocytes, B-lymphocytes, mast cells, endothelial cells, fibroblasts and stromal cells) when stimulated by a pathogen. CBD inhibits cytokine and IL-6 (pro-inflammatory) production.In one interesting study, researchers decided to test the effect of CBD on four cell signaling or mediating molecules associated with intestinal inflammation and oxidative damage to the gut. Their findings were as follows:Inducible nitric oxide synthase (iNOS) – CBD reduced the overexpression of iNOS in response to colitis. iNOS overexpression is well correlated with disease activity with colitis, and inhibitors of iNOS lead to improvement in experimental models of IBD. iNOS results in high-output production of NO, which results in oxidative damage to the intestine via reactive oxygen species (ROS).Interleukin-1β – levels significantly increased with experimental colitis. CBD was shown to decrease levels. IL-1β is shown to have potent pro-inflammatory activity and thus heightens the inflammatory response that leads to intestinal injury. IL-1β amplifies the production of inflammatory leukocytes (immune system cells), resulting in an increase of inflammation.Interleukin-10 – levels significantly decreased with experimental colitis. CBD was shown to restore levels. IL-10 has anti-inflammatory activity by inhibiting the release of pro-inflammatory cytokines. Restoration of IL-10 activity is critical to intestinal health.The reduction of iNOS and reactive oxygen species by CBD, along with the reduction of lipid peroxidation, shows the important therapeutic action of CBD in reduction of colonic inflammation by indirect reduction of oxidative damage. In addition, the dysregulation of the interleukins IL-1B and IL-10 is a well-known disruption caused by irritable bowel disease (IBD). The restoration of these interleukins to normal behavior by CBD, although the specific pathway is unknown, is another important therapeutic action that CBD has on reduction of colonic inflammation.It is the CBD in marijuana that is being researched to treat mTBI and other head traumas. Athletes in the US have been using marijuana for decades, often to relax them but without (or with) factual knowledge been using it to recover their bodies from inflammation and the pain they undergo in order to perform at their peak right away.DosageRegarding dosage, most clinical trials show CBD dosing ranging from 10-800 mg of CBD per day (although to treat schizophrenia, doses may be as high as 1,300mg). But everyone is different and you’ll likely need to experiment with a dosage range that works for you. A lot of this also depends on absorption. Not all CBD supplements are created equal. AbsorptionWhat is the purpose of consuming something beneficial if your body cannot absorb it? Most hemp CBD carries a particle size of 150 nm to 5,000 nm. This makes it nearly impossible to fully absorb and even to cross the blood/ brain barrier. CBD Oils such as Naked Jane use a nano-emulsion system that bring the particle size down to 25 nm-60 nm making this in of itself better bioavailable. This means that a hybrid-nanoengineered CBD is over 10x more bioavailable in the body than any other oil based CBD and that just 10mg of a nanoparticle CBD is comparable to 100 mg of standard CBD.Combining a nano-emulsion system in cannabinoids and terpenoids in CBD with the isolated curcuminoids of a high-curcumin containing turmeric plant, the bioavailability of the CBD increases even greater!!! As curcumin in of itself is poorly absorbed, combining it with piperine will create the mack daddy of all absorption.
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