Genetics (Audio)

Welcome and introductory remarks to the symposium: Cellular and Molecular Explorations of Anthropogeny Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32977]

Concluding remarks and question and answer session for the symposium: Cellular and Molecular Explorations of Anthropogeny. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32978]

The human brain is one of, if not the most important factor that distinguishes our species from all others. Three experts explore the use of stem cells in understanding the primate brain, genes that guided the evolution of the human brain, and the features that enabled the expansion of human neural characteristics. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32927]

The human genome impacts human health and our risk for psychiatric and developmental disorders. Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics, Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to give a brief overview of the human genome, the blueprint to human development. Series: "Brain Channel" [Health and Medicine] [Show ID: 33102]

The Salk Institute's Rusty Gage and University of Washington's Evan Eichler explore the mechanisms and evolutionary pathways that have differentiated human neural development and allowed for the emergence of genes found only in humans. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 32926]

Can we turn off the genes responsible for neurodegenerative diseases? Designer DNA drugs are making this possible. By identifying and targeting the genes that drive disease, scientists are moving closer to treatments for ALS, Huntington's disease, and more. Don W. Cleveland, PhD, Department of Cellular and Molecular Medicine, UC San Diego joins William Mobley, MD, PhD to talk about how these drugs work and how they will impact patient care. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 32505]

What effect does space travel have on our bodies and minds? As NASA looks to explore Mars and beyond, it is critical to understand the impacts of spending extended time in space. Brinda K. Rana, Phd, shares the results of NASA's Twins Study that focused on astronaut Scott Kelly who spent nearly one year living on the International Space Station and his identical twin brother, Mark, who remained on Earth. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Science] [Education] [Professional Medical Education] [Show ID: 31842]

Researchers at the UC San Diego Stem Cell Program have used a rare disorder, Aicardi Goutieres (AGS), to explore fundamental brain mechanisms.

By utilizing cortical organoids, or brains in a dish, they have tracked neurodevelopment while discovering new information about the relationship between retrotransposons and neuroinflammation.

Series: "UCTV Prime" [Health and Medicine] [Show ID: 32743]

In this talk, Ajit Varki (UC San Diego) offers some surprising examples of common human diseases that appear to be either absent in our closest living evolutionary cousins (the so-called "great apes"), or manifest in a rather modified form. Given the close genetic similarity of all of these species, he contends that it is worth investigating these differences, with the goal of better understanding the pathological processes involved.

Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Science] [Show ID: 31604]

A single tumor cell can contain thousands of genetic mutations, some of which provide critical information about the precise cancer type and provide clues about which therapy may be effective. Hear how genome-based analysis is improving diagnosis and treatment. Series: "Patient-Centered Care in the 21st Century - UCSF Cancer Showcase " [Health and Medicine] [Show ID: 32380]