In a wide-ranging interview, Dr. Sylvain Charlebois ("The Food Professor") discusses whether lab-grown (cellular) meat is overhyped, citing consumer acceptance, cost, and labeling as key barriers, though he found lab-grown chicken indistinguishable in taste and notes potential for nutrient customization. The conversation then turns to Canadian food inflation, arguing there is little evidence grocers are gouging consumers via higher margins, though grocers pressure suppliers through fees, affecting prices and supply-chain discipline. Charlebois contends food inflation is largely structural and policy-driven, pointing to trade barriers, carbon tax impacts, logistics, supply management, counter-tariffs, and the GST holiday's inflationary effect. He proposes solutions focused on competition, tax relief, logistics investment, and policy reform, and closes with a cautious view of ultra-processed food rhetoric, emphasizing consumer information over bans.

Dr. Sylvain Charlebois is a professor of food distribution and policy at Dalhousie University and director of the Agri-Food Analytics Lab, where his work focuses on food distribution, food policy, food security, and food safety. Widely known as "The Food Professor," he is one of Canada's most recognized voices on food inflation, grocery pricing, supply chains, and the future of food. His research has been featured in major outlets including The Economist, The New York Times, The Wall Street Journal, and The Globe and Mail, and he also hosts The Food Professor Podcast. In this episode, he breaks down what's really driving food prices in Canada, whether grocers are being unfairly blamed, the debate around lab-grown meat, and how ultra-processed foods and GLP-1 drugs are reshaping the food industry.

Sylvain / The Food Professor

The Food Professor on X — https://x.com/FoodProfessor

Sylvain Charlebois on LinkedIn — https://ca.linkedin.com/in/thefoodprofessor

The Food Professor Podcast — https://the-food-professor.simplecast.com/

Food Tech / Salmon

AquaBounty — https://aquabounty.com/our-salmon/why-aquabounty-salmon

FDA AquAdvantage Salmon Fact Sheet — https://www.fda.gov/animal-veterinary/aquadvantage-salmon/aquadvantage-salmon-fact-sheet

Sustainable Blue — https://www.sustainableblue.com/

Canada Food Policy / Data

Canada Grocery Code of Conduct — https://canadacode.org/

Code of Conduct Page — https://canadacode.org/code/code-of-conduct/

Health Canada Front-of-Package Nutrition Symbol — https://www.canada.ca/en/health-canada/services/food-nutrition/nutrition-labelling/front-package.html

Statistics Canada Household Income — https://www.statcan.gc.ca/hub-carrefour/quality-life-qualite-vie/prosperity-prosperite/household-income-revenu-menage-eng.htm

CUSMA — https://www.international.gc.ca/trade-commerce/trade-agreements-accords-commerciaux/agr-acc/cusma-aceum/index.aspx?lang=eng

GST/HST Holiday Page — https://www.canada.ca/en/services/taxes/child-and-family-benefits/gst-hst-holiday-tax-break.html

David Dodge, Bank of Canada Profile — https://www.bankofcanada.ca/profile/david-dodge/

Companies / Brands Mentioned

Loblaw Companies — https://loblaw.ca/

Sobeys — https://www.sobeys.com/

Walmart Canada — https://www.walmartcanada.ca/

CBC Organization Profile — https://federal-organizations.canada.ca/profil.php?OrgID=CBC&lang=en

Johnson & Johnson — https://www.jnj.com/

McDonald's Canada — https://www.mcdonalds.com/ca/en-ca.html

GLP-1 / Weight Loss Drugs

Ozempic Canada — https://www.ozempic.ca/en_ca.html

Wegovy Canada — https://www.wegovy.ca/en_ca.html

Media / Podcast Reference

The Joe Rogan Experience — https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk

Show Notes

00:00 Welcome to the Hart2Heart Podcast

00:37 Lab Meat Hype Cycle

01:50 How Cultured Meat Works

03:06 Acceptance and Cost Barriers

04:46 Taste Test and Nutrition Tweaks

06:54 Vegans Vegetarians and Labeling

14:53 Canada Food Inflation Debate

15:57 Grocers Fees and Supplier Squeeze

17:40 Policy Roots and Middle Class Squeeze

21:06 Fixes Without More Spending

23:27 Supply Management Price Premiums

24:51 Politics Crises and Inflation Spending

26:53 Inflation And Taxes

27:38 Conservative Policy Impact

28:19 Grocer Margins And Manufacturing

30:05 GST Holiday Backfire

33:18 Media Blind Spots

35:05 Counter Tariffs Price Ripple

37:41 Carney Versus Poilievre

42:53 Media Subsidies And CBC

44:39 Ultra Processed Food Debate

48:54 Addiction Obesity And GLP1

51:30 Regulation Tradeoffs Wrap Up

52:51 Where To Follow Closing

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart interviews Dr. Russell Kennedy about chronic anxiety as a childhood safety adaptation that never turns off, driven more by a body-based "alarm" than by thinking. Kennedy explains why understanding anxiety and talk-based cognitive approaches often have limited effect because subcortical systems communicate through feeling; alarm sensations trigger the mind to generate worries, which can become dopamine-reinforced and addictive. He discusses sensitivity (often cited as 15–20% of the population), modern stressors like smartphones and social media reducing discomfort tolerance, and high-functioning anxiety in high achievers and physicians, with sleep as a key regulation marker. Kennedy emphasizes reconnecting mind and body and adult self with younger self using somatic techniques (body scanning, hand placement, "sensation without explanation," and the SHOULD acronym), notes trauma can occur without an overtly traumatic life, links dysregulated autonomic states to varied symptoms, and shares rapid tools like the physiological sigh and alternate nostril breathing, plus his "Sanity" app and AnxietyMD resources.

Dr. Russell Kennedy is a physician, author, and anxiety expert whose work explores the deeper roots of chronic anxiety, especially the role of childhood stress, nervous system dysregulation, and the body's stored alarm response. In this episode, he explains why anxiety is not just a thinking problem but a feeling problem, how worry becomes a coping pattern that keeps people stuck, why high performers often live in a state of hidden dysregulation, and how self-connection, somatic awareness, and better sleep can help break the cycle. Through a blend of clinical experience, neuroscience, and personal insight, Kennedy helps listeners better understand where anxiety comes from and what it actually takes to heal it at the root.

Official site:

https://www.dr-russ.com/

Instagram:

https://www.instagram.com/theanxietymd/

YouTube:

https://www.youtube.com/c/DrRussellKennedyTHEANXIETYMD

Therapies Mentioned

Internal Family Systems (IFS):

https://ifs-institute.com/

Somatic Experiencing / somatic therapy:

https://traumahealing.org/

Physiological sigh:

https://www.hubermanlab.com/newsletter/breathwork-protocols-for-health-focus-stress

Alternate nostril breathing:

https://www.health.harvard.edu/healthy-aging-and-longevity/alternate-nostril-breath

Pain / Neuroplasticity Resources

Alan Gordon / Pain Psychology Center:

https://painpsychologycenter.com/our-team

Pain Reprocessing Therapy:

https://www.painreprocessingtherapy.com/

Experts Mentioned

David Goggins:

https://davidgoggins.com/

Joseph LeDoux:

https://www.joseph-ledoux.com/

Dr. Ethan Russo:

https://ethanrusso.org/

Clinical endocannabinoid deficiency paper (PubMed):

https://pubmed.ncbi.nlm.nih.gov/15159679/

Show Notes

00:00 Welcome to the Hart2Heart Podcast

01:19 Anxiety Starts in the Body

03:17 Sensitivity and Modern Stress

05:58 The Dopamine Worry Loop

08:08 Self Connection Over Self Punishment

09:09 High Functioning Anxiety and Burnout

12:41 Redefining Success Internally

17:19 Discipline vs Dysregulation

21:46 Mind Body Child Separation

27:10 Finding the Alarm Sensation

29:16 Somatic Steps to Soothe Alarm

33:18 Why We Should Say Alarm

35:07 Medicine Limits and SSRIs

35:36 Medicine Misses Root Causes

36:57 Trauma Behind Weird Symptoms

38:58 Fibro IBS and Nervous System

42:31 Forgiveness and Doctor Burnout

50:51 Biohacking Anxiety Spiral

56:56 Somatic Healing and Spirit

01:02:50 Psychedelics Need Foundation

01:03:39 Physiological Sigh Tools

01:06:24 App Plug and Farewell

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Mike Hart interviews elite runner Brady Holmer about endurance training, VO2 max physiology, and common misconceptions. Holmer explains that zone 2 builds the aerobic base and enables high training volume with less fatigue, notes heart-rate zones are ideally defined by lactate thresholds, and says he primarily uses perceived exertion rather than lactate or heart rate during training. He advises against guiding workouts by wearable HRV scores, arguing accurate HRV requires standardized morning measurements and that wearable data can create a nocebo effect; trends may be informative, but subjective feel should come first. They discuss polarized vs pyramidal training and typical 80/20 intensity distributions, effective session durations, mechanisms limiting VO2 max (central vs peripheral), and why Norwegian 4x4 intervals work by maximizing time near 85–90% max heart rate. They cover breathing/nose breathing, inspiratory muscle training, sauna/hot baths as performance adjuncts, nutrition timing of carbohydrates, and supplements including beetroot, beta-alanine, urolithin A, and post-exercise ketones.

Brady Holmer is an endurance-focused performance expert and elite runner whose work explores the science and practice of aerobic fitness, VO2 max, recovery, and smarter cardio training. In this episode, he explains how zone 2 training builds the foundation for endurance, why HRV and wearable data should be interpreted carefully, and how protocols like Norwegian 4x4 can improve performance when used in the right context. Through a blend of long-term training experience, research literacy, and practical coaching insight, Holmer helps listeners better understand how to train harder, recover smarter, and think more clearly about what actually improves cardiovascular fitness.

Training & Cardio

Zone 2 Cardio

Overview (Cleveland Clinic): https://health.clevelandclinic.org/zone-2-cardio

Lactate / Threshold-Based Training

Threshold zones review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC6537749/

Lactate-guided threshold interval training (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC10000870/

Norwegian 4x4

Classic VO2 max paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/17414804/

4x4 protocol heart-rate response study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC7399937/

Polarized Training

Meta-analysis / review (PubMed): https://pubmed.ncbi.nlm.nih.gov/38717713/

Older landmark paper (PubMed): https://pubmed.ncbi.nlm.nih.gov/24550842/

Pyramidal Training

Pyramidal vs. polarized study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC9299127/

HRV & Wearables

Marco Altini

Official site: https://www.marcoaltini.com/

HRV4Training: https://www.hrv4training.com/

HRV Measurement / Use

HRV4Training article with Marco Altini: https://www.hrv4training.com/blog2/heart-rate-variability-hrv-training-with-dr-marco-altini-how-to-exercise-using-hrv

Oura Ring

Official: https://ouraring.com/

WHOOP

Official: https://www.whoop.com/

Experts & Writing

Dr. Andy Galpin

Official site: https://www.andygalpin.com/

Brady Holmer

Substack profile: https://substack.com/@bradyholmer

Physiologically Speaking: https://www.physiologicallyspeaking.com/

Supplements & Recovery

Exercise / Performance Supplements

NIH overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/

Creatine

Cleveland Clinic overview: https://my.clevelandclinic.org/health/treatments/17674-creatine

Beta-Alanine

NIH consumer overview: https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-Consumer/

ISSN position stand (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4501114/

Beetroot / Dietary Nitrate

Review (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC4008816/

Meta-analysis (PubMed): https://pubmed.ncbi.nlm.nih.gov/23580439/

Urolithin A

Mitopure / official: https://www.mitopure.com/

Altitude training camp study (PMC): https://pmc.ncbi.nlm.nih.gov/articles/PMC12628386/

Exogenous Ketones

Ketone-IQ official: https://ketone.com/

Post-exercise ketone monoester and EPO study (PubMed): https://pubmed.ncbi.nlm.nih.gov/36449571/

Post-exercise ketones improved endurance training adaptations study (PubMed): https://pubmed.ncbi.nlm.nih.gov/41757674/

Show Notes

00:00 HRV Training Myth

00:59 Zone Two Benefits

02:11 Finding True Zone Two

03:59 RPE Over Wearables

06:27 HRV Done Right

12:06 80 20 Training Split

15:23 Zone Two Session Length

18:37 Cardio Adaptation Science

24:03 Norwegian 4x4 Explained

30:30 Sports Versus Machines

32:54 Leg Day Timing Tips

34:58 Best Leg Exercises

38:21 Nordic Curl Reality Check

39:11 Portable Nordic Setup Tips

39:51 Biggest Running Mistake

40:18 Nose Breathing Zone Two

42:16 Breathing Tools And Myths

43:08 Inspiratory Muscle Training

44:51 How Much Benefit Really

46:27 Sauna For VO2 Max

48:35 Heat Mimics Altitude

50:59 Sauna Fertility Debate

52:54 Red Light Therapy Reality

54:30 Carbs Fuel The Work

56:25 Timing Carbs Around Training

57:52 Best Carb Food Choices

59:41 Supplements For Cardio

01:00:20 Creatine Beta Alanine Beetroot

01:02:16 Urolithin A Breakthrough

01:05:01 Ketones After Training

01:07:31 Other Supplements And Caffeine

01:09:07 SARMs Peptides And Doping

01:10:10 VO2 Max And Longevity

01:10:49 Wrap Up And Where To Follow

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Tommy Wood discusses evidence that stimulants can help people with ADHD but may worsen complex cognitive performance in non-ADHD users despite feeling more focused. He outlines an ideal brain-health day centered on consistent sleep opportunity, morning caffeine timed to protect sleep, nutrient-dense meals (protein, B vitamins, omega-3s, fiber, antioxidants), frequent movement to break up sedentary time, and structured exercise including cardio, resistance training, HIIT (notably Norwegian 4x4), and open-skill sports for added cognitive benefits. He emphasizes bright morning light and darkness at night for circadian strength, notes optic-flow/nature exposure as helpful but not required, and says electrolytes/salt needs are individual. The conversation covers cognitive decline and bioenergetics/mitochondria, critiques "type 3 diabetes" as oversimplified, reviews mixed evidence for ketones, and addresses supplements (omega-3s, vitamin D, saffron, creatine, polyphenols). Screens can help or harm depending on use and what they displace. Wood promotes his book, "The Stimulated Mind," out March 24.

Dr. Tommy Wood is a physician-scientist and brain health expert who helps people better understand how to improve cognition, protect memory, and reduce long-term dementia risk. With a focus on exercise, sleep, nutrition, and brain energetics, he explores the practical habits that support focus, processing speed, recovery, and healthy cognitive aging. Dr. Wood is known for translating complex neuroscience into clear, actionable advice, while challenging oversimplified ideas around stimulants, supplements, and modern brain optimization.

Through his research, speaking, and new book The Stimulated Mind, Dr. Wood teaches people how to create the right conditions for better brain function across the lifespan. His work empowers listeners to think of brain health as something trainable—shaped by movement, sleep, learning, and the quality of the inputs we give our minds every day.

Books & Main Episode Resources

The Stimulated Mind

Official book page: https://www.drtommywood.com/stimulated-mind

Publisher page: https://www.penguinrandomhouse.com/books/751292/the-stimulated-mind-by-dr-tommy-wood/

Dr. Tommy Wood

Official website: https://www.drtommywood.com/

Instagram: https://www.instagram.com/drtommywood/

Podcasts, People & Platforms

The Diary of a CEO

Official show page: https://stevenbartlett.com/doac/

Joe Rogan Experience

Official site: https://www.joerogan.com/

Spotify show page: https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk

Dr. Rhonda Patrick / FoundMyFitness

Official site: https://www.foundmyfitness.com/

About Dr. Rhonda Patrick: https://www.foundmyfitness.com/about-dr-rhonda-patrick

Medications & Prescription Drugs Mentioned

Provigil (modafinil)

DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e16c26ad-7bc2-d155-3a5d-da83ad6492c8

Vyvanse (lisdexamfetamine)

DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=704e4378-ca83-445c-8b45-3cfa51c1ecad

Concerta (methylphenidate)

Official prescribing info: https://www.jnjlabels.com/package-insert/product-monograph/prescribing-information/CONCERTA-pi.pdf

Adderall

DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81

Adderall XR

DailyMed label: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0

Aricept (donepezil)

FDA label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020690s042,021720s014,022568s011lbl.pdf

Hydration / Electrolytes

LMNT

Official site: https://drinklmnt.com/

Research, Labs & Studies Mentioned

COSMOS Trial

Official site: https://cosmostrial.org/

ClinicalTrials.gov: https://clinicaltrials.gov/study/NCT03035201

Institute for Human and Machine Cognition (IHMC)

Official site: https://www.ihmc.us/

Jonathan Little Lab (UBC)

Faculty page: https://hes.ok.ubc.ca/about/contact/jonathan-little/

Lab site: https://emil.ok.ubc.ca/

Show Notes

00:00 Stimulants Backfire

00:56 Plan Sleep First

02:33 Caffeine Timing

04:24 Brain Food Basics

05:12 Move All Day

06:00 Workouts That Help

07:26 Social Connection Matters

08:36 Sunlight Optic Flow Hydration

13:31 Exercise Types Compared

16:02 HIIT Lactate Brain Boost

18:18 Open Skill Sports

21:45 ADHD Meds Long Term

26:51 Which Med Is Best

27:59 Cognitive Decline Energy

28:27 Brain Energy Risk Factors

29:04 Stimulus Drives Brain Health

30:57 Type Three Diabetes Debate

33:42 Ketones and Cognition

37:13 Mitochondria and Decline

38:42 Omega Three Practical Dosing

41:45 Vitamin D and Dementia Risk

43:13 Saffron Hype Check

45:03 Creatine for the Brain

50:28 Polyphenols Diet vs Pills

52:41 Screens AI and Brain Use

55:31 Book Plug and Wrap Up

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

The script explains why fiber is critical for gut and metabolic health, focusing on how soluble fiber is fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate). It contrasts soluble fiber (forms a gel, lowers LDL by binding bile acids, slows glucose absorption, increases satiety, feeds the microbiome) with insoluble fiber (adds stool bulk, helps constipation). It highlights research showing 10 g/day psyllium husk (Metamucil) is linked to a 10% reduction in all-cause mortality and typically lowers LDL about 7–15%. Butyrate is emphasized as the primary fuel for colonocytes, supporting gut barrier integrity and potentially reducing colon cancer risk, while also affecting mitochondria, inflammation, and the brain. Propionate influences liver cholesterol production and satiety hormones, and acetate provides systemic energy. Practical supplementation "stacks," dosing ranges, food sources, GI side effects, and timing cautions (e.g., separating psyllium from minerals) are discussed.

Metamucil (psyllium husk fiber) — https://www.metamucil.com/

Psyllium husk (soluble fiber) — https://medlineplus.gov/druginfo/meds/a601104.html

Psyllium husk (PubMed search) — https://pubmed.ncbi.nlm.nih.gov/?term=psyllium+husk

Soluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html

Insoluble fiber (overview) — https://medlineplus.gov/dietaryfiber.html

Inulin (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=inulin+prebiotic+fiber

Acacia fiber / Gum arabic (prebiotic fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=acacia+fiber+gum+arabic+prebiotic

Beta-glucan (oats/barley soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=beta-glucan+oats+LDL

Pectin (soluble fiber) — https://pubmed.ncbi.nlm.nih.gov/?term=pectin+soluble+fiber

Partially hydrolyzed guar gum (PHGG) — https://pubmed.ncbi.nlm.nih.gov/?term=partially+hydrolyzed+guar+gum

Resistant starch / Potato starch — https://pubmed.ncbi.nlm.nih.gov/?term=resistant+starch+potato+starch

Short-chain fatty acids (SCFAs) — https://www.ncbi.nlm.nih.gov/books/NBK557571/

Butyrate (SCFA) — https://pubmed.ncbi.nlm.nih.gov/?term=butyrate+short-chain+fatty+acid+colonocytes

LDL cholesterol (general) — https://medlineplus.gov/cholesterol.html

Magnesium (mineral supplement info) — https://medlineplus.gov/magnesium.html

Show Notes

00:00 Butyrate and Colon Health

00:49 Why Fiber Matters Now

02:28 How Fiber Is Digested

03:45 Soluble vs Insoluble Fiber

06:36 Gel Effect on Blood Sugar

07:36 How Soluble Fiber Lowers LDL

10:19 Short Chain Fatty Acids 101

11:32 Butyrate Deep Dive

16:40 Propionate and Liver Benefits

18:22 Acetate for Energy and Appetite

19:29 Best Fibers to Supplement

21:33 Dosing and Food Sources

24:44 Ideal Fiber Stack and Safety

28:37 Wrap Up and Next Steps

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Dr. Roger McFillin argues that Western allopathic medicine and psychiatry have medicalized normal human suffering by reducing emotions to biological or chemical reactions, turning symptom checklists into fixed identities, and sustaining a drug-driven "sick care" system that creates lifelong customers. He contrasts this with viewing emotions as powerful energy meant to be moved into creation and transformation, cites psychoneuroimmunology, and warns that suppressing fear and distress with pharmaceuticals can worsen long-term outcomes. The conversation covers exposure-based approaches to unlearn fear, the role of media, social media, and advertising in provoking fear and keeping people in an unconscious "drift" state, and the importance of intentional stillness, solitude (distinct from loneliness), prayer or silent meditation, and reducing phone use—especially at the start of the day—to become more conscious and intentional.

McFillin discusses how diagnostic labels like depression and anxiety shape identity, limit choices, and contribute to chronicity and polypharmacy. He contrasts PTSD with post-traumatic growth, emphasizing processing trauma memories, facing avoided situations, challenging overgeneralized threat beliefs, and practicing forgiveness and self-compassion while also taking ownership where appropriate. They also discuss the perceived harms of the "toxic masculinity" concept, men's wellbeing, the loss of wise elders, and how men often bond and cope through shared activities.

Dr. Roger McFillin is a clinical psychologist and trauma recovery expert who challenges the medicalization of normal human emotions. With a focus on emotional resilience and personal growth, he specializes in exposure therapy and psychoneuroimmunology, exploring the connection between mind, emotions, and immune health. Dr. McFillin advocates for self-regulation and transforming emotional energy into healing, critiquing the overuse of pharmaceuticals in modern mental health treatment.

Through his Substack, Radically Genuine, and podcast, Dr. McFillin educates individuals on overcoming fear, achieving stillness, and reconnecting with their true selves. His work empowers people to shift from a victim mindset to one of active growth, using trauma as a catalyst for resilience and positive change.

Science & Medicine

Psychoneuroimmunology

Overview & science (NIH): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130991/

Exposure Therapy

Wikipedia overview: https://en.wikipedia.org/wiki/Exposure_therapy

Cleveland Clinic explanation: https://my.clevelandclinic.org/health/treatments/25067-exposure-therapy

Anxiety & OCD exposure-based approaches (IOCDF): https://iocdf.org/about-ocd/treatment/erp/

Heart Coherence

HeartMath Institute overview: https://www.heartmath.org/heart-coherence/

Psychiatric Diagnosis & DSM

Critique of DSM and diagnostic categories: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195174/

Psychiatric diagnosis controversies: https://www.apa.org/monitor/2013/04/diagnosis

Psychology & Healing

Post-Traumatic Growth vs. PTSD

Scientific overview of post-traumatic growth: https://www.apa.org/monitor/2014/01/psychological-recovery

Journal article on PTG vs PTSD: https://www.sciencedirect.com/science/article/abs/pii/S0272735814000412

Forgiveness and Healing

Psychology Today on forgiveness: https://www.psychologytoday.com/us/basics/forgiveness

Research evidence on forgiveness and wellbeing: https://journals.sagepub.com/doi/10.1177/1745691614568356

Self‑Healing Practices

Grounding / Earthing

What is grounding/earthing? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/

PEMF (Pulsed Electromagnetic Field) Therapy

Basics of PEMF therapy: https://www.health.harvard.edu/pain/pulsed-electromagnetic-field-therapy

Meditation & Stillness

Mindfulness & stillness research: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422583/

Psychology Today on solitude and healing: https://www.psychologytoday.com/us/blog/hide-and-seek/201209/finding-solitude-its-benefits-and-challenges

Cultural & Media Influence

Mind Control & Fear Provocation

The psychology of fear in media messaging: https://www.frontiersin.org/articles/10.3389/fpsyg.2020.566245/full

Media influence and persuasion research: https://www.communicationtheory.org/agenda-setting-theory/

Toxic Masculinity

Research overview on toxic masculinity: https://www.apa.org/advocacy/health-men/guidelines

What toxic masculinity means: https://www.psychologytoday.com/us/blog/the-masculine-mind/201802/what-toxic-masculinity

Dr. Roger McFillin Content

Substack (Radically Genuine): https://drmcmillan.substack.com

Show Notes

00:00 Emotions as Energy

00:33 Medicalizing Suffering

02:44 Exposure Beats Suppression

05:18 Fear and Mind Control

10:21 Stillness vs Loneliness

14:47 Simple Stillness Practices

20:12 Morning Intention Rituals

25:56 Labels and Identity Traps

31:26 Systemic Treatment Harm

32:53 Depression Label Identity

35:08 Sadness Versus Pathology

36:10 PTSD And Growth

38:24 Processing Trauma Fully

41:44 Practical Recovery Steps

45:48 Forgiveness And Ownership

50:37 Toxic Masculinity Debate

56:12 Men Friendship And Elders

01:01:05 Closing Plugs Farewell

38:24 How PTSD Develops

41:44 Practical Trauma Recovery

45:48 Forgiveness and Ownership

50:37 Toxic Masculinity Debate

56:12 Male Friendship and Elders

01:01:05 Closing and Where to Follow

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.

The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.

Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.

Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html)

Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)

Key mechanisms mentioned

Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/)

Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)

Conditions mentioned in the episode

Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html)

Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)

Blood pressure drug mentioned

Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)

Other longevity / comparison drugs mentioned

Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html)

Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)

Side-effect helper mentioned

Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)

Dementia meds mentioned

Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html)

Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)

Lab markers mentioned

Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/)

Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)

People referenced (where the claims were mentioned)

Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/)

Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334)

Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/)

Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)

Show Notes

00:00 Welcome to the Hart2Heart Podcast.

01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained

03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH

05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits

06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease

11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia

13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis

15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity

16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential

18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this podcast episode, an in-depth discussion is provided on the drug Telmisartan, commonly used for lowering blood pressure. The host elaborates on how it belongs to a class of medications known as angiotensin receptor blockers (ARBs) and stands out due to its 24-hour half-life and partial PPAR-gamma agonist activity.

The episode explores Telmisartan's potential benefits for longevity, including its properties that reduce cardiovascular mortality, renal decline, and metabolic issues. It also compares Telmisartan with other ARBs and addresses its unique ability to improve myocardial efficiency, reduce arterial stiffness, and support neuroprotection. Detailed explanations are given on technical concepts such as pulse pressure and its relevance to arterial compliance, and the necessity to consult a doctor before taking the medication is emphasized.

Telmisartan / ARBs (main topic) Telmisartan — MedlinePlus drug info: https://medlineplus.gov/druginfo/meds/a601249.html Blood pressure meds overview (includes ARBs): https://medlineplus.gov/bloodpressuremedicines.html

Key mechanisms mentioned PPARγ (PPARG) — NCBI Gene: https://www.ncbi.nlm.nih.gov/gene/5468 Endothelium + nitric oxide (NO) — NCBI Bookshelf: https://www.ncbi.nlm.nih.gov/books/NBK534266/

Angiotensin / aldosterone / "fight-or-flight" Aldosterone test — MedlinePlus lab test: https://medlineplus.gov/lab-tests/aldosterone-test/ Sympathetic nervous system ("fight-or-flight") — Cleveland Clinic explainer: https://my.clevelandclinic.org/health/body/23262-sympathetic-nervous-system-sns-fight-or-flight

Lab tests mentioned in the episode Fasting insulin ("Insulin in Blood") — MedlinePlus lab test: https://medlineplus.gov/lab-tests/insulin-in-blood/ Hemoglobin A1C (HbA1c) — MedlinePlus lab test: https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/ C-reactive protein (CRP) — MedlinePlus lab test: https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/

Arterial stiffness / pulse pressure (longevity framing) Pulse pressure & arterial stiffness as risk predictors — PubMed: https://pubmed.ncbi.nlm.nih.gov/11224702/

Visceral fat resource mentioned Dr. Sean O'Mara website: https://drseanomara.com/

Show Notes

00:00 Welcome to the Hart2Heart Podcast.

01:22 Understanding Angiotensin and Its Effects

02:14 How ARBs Work and Their Benefits

03:00 Unique Properties of Telmisartan

03:36 Comparing Telmisartan with Other ARBs

04:44 Telmisartan's Impact on Endurance and Fat Loss

05:59 Telmisartan and Cardiovascular Health

09:57 Blood Pressure Basics and Pulse Pressure

18:54 Telmisartan's Role in Longevity and Dosing

27:28 Conclusion and Final Thoughts

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this podcast episode, the speaker shares his personal journey of quitting THC, explaining his reasons, the gradual process over several years, and the impacts on his life. He recounts his history with THC, from early recreational use to daily dependence for sleep aid during medical school and residency. The speaker emphasizes that he does not oppose cannabis, recognizing its medicinal value, but wanted to overcome his dependency. He details his method of reducing THC use through vaping and CBD alternatives, ultimately leading to his last use in January 2025. Alongside his personal story, he discusses the benefits and potential negative impacts of THC and other cannabinoids, offering insights into who might consider quitting and why.

Cannabis, THC & Quitting

Cannabis (Marijuana) — NIDA overview:

https://nida.nih.gov/research-topics/cannabis-marijuana

Cannabis Use Disorder — NCBI Bookshelf (StatPearls):

https://www.ncbi.nlm.nih.gov/books/NBK538131/

Sleep, REM & Withdrawal

Cannabis and sleep architecture — systematic review (PubMed):

https://pubmed.ncbi.nlm.nih.gov/40967124/

Effects of cannabinoids on sleep — review (PMC):

https://pmc.ncbi.nlm.nih.gov/articles/PMC8116407/

Non-Intoxicating Cannabinoids Mentioned

CBD + anxiety — systematic review (PMC):

https://pmc.ncbi.nlm.nih.gov/articles/PMC11595441/

CBG — acute effects + cognition (PMC):

https://pmc.ncbi.nlm.nih.gov/articles/PMC11246434/

THCV — overview/commentary (PubMed):

https://pubmed.ncbi.nlm.nih.gov/33526143/

CBC — therapeutic potential review (PMC):

https://pmc.ncbi.nlm.nih.gov/articles/PMC11493452/

Potency: Concentrates

Marijuana Concentrates — NIDA DrugFacts PDF:

https://nida.nih.gov/sites/default/files/df-marijuana-concentrates.pdf

Supplements Mentioned

Omega-3 Fatty Acids — NIH ODS (Consumer):

https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/

Vitamin D — NIH ODS (Consumer):

https://ods.od.nih.gov/factsheets/VitaminD-Consumer/

Show Notes

00:00 Introduction: Why I Quit THC

02:18 My History with THC

06:10 Transition to Medical Use

13:53 The Quitting Process

20:11 Benefits and Challenges of Quitting

25:07 Thoughts on THC and Other Cannabinoids

33:25 Conclusion and Final Thoughts

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

Connect with Dr. Mike Hart

Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Most people think they go into your body and make all new tissue… but in actuality, they are a delivery mechanism of growth factors. I call them the ultimate traffic cop.

In this episode, the host converses with Dr. Jesse Morse, a physician specializing in regenerative and anti-aging medicine. They delve into the intricacies of stem cells and their various sources, including bone marrow, fat, and donor tissue.

Dr. Morse highlights the role of exosomes and growth factors in the healing process. The discussion also focuses on the prevention and treatment of Achilles tendon tears, emphasizing the importance of blood supply, proper diagnosis, and innovative therapies. Additionally, they explore the benefits and applications of various peptides, including BPC 157, TB 500, and MotC, for enhancing healing, anti-aging, and overall health. Dr. Morse also addresses the significance of nutrition and detoxification in maintaining optimal health and preventing injuries. Dr. Jesse Morse is a Miami-based, double board-certified physician in Family and Sports Medicine who specializes in regenerative medicine, injury recovery, and longevity. Since shifting from traditional sports medicine in 2020, he has focused on non-surgical approaches to tendon and ligament injuries using therapies like PRP, stem-cell–based treatments, exosomes, and peptides, alongside functional and anti-aging strategies centered on mitochondrial health, immune support, toxin reduction, and personalized recovery—helping everyone from active adults to high-performance athletes restore function and prevent major injuries like Achilles tears while educating widely online. Connect with him on: Instagram: https://www.instagram.com/drjessemorse/ — Sports medicine, regenerative medicine & insights

Linktree (aggregated links to socials & resources): https://linktr.ee/DrJesseMorse

Supplements, Compounds & Peptides

Collagen (protein / connective tissue support): https://www.ncbi.nlm.nih.gov/books/NBK507922/

Vitamin C (collagen activation / antioxidant): https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/

Creatine (muscle & mitochondrial support): https://ods.od.nih.gov/factsheets/Creatine-HealthProfessional/

BPC-157 (peptide – tendon & gut healing): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504390/

TB-500 / Thymosin Beta-4 (peptide – tissue repair): https://pubmed.ncbi.nlm.nih.gov/22674782/

GHK-Cu (copper peptide – skin, joints, stem-cell signaling): https://pubchem.ncbi.nlm.nih.gov/compound/GHK-Cu

MOTS-c (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/25174616/

SS-31 / Elamipretide (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/29515116/

Thymosin Alpha-1 (immune modulation peptide): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367996/

LL-37 (antimicrobial / immune peptide): https://pubmed.ncbi.nlm.nih.gov/15184378/

5-Amino-1MQ (NNMT inhibitor / fat loss): https://pubchem.ncbi.nlm.nih.gov/compound/5-Amino-1MQ

N-Acetylcysteine (NAC – liver & detox support): https://www.ncbi.nlm.nih.gov/books/NBK537183/

Glutathione (antioxidant / detox): https://ods.od.nih.gov/factsheets/Glutathione-HealthProfessional/

NAD⁺ / NMN / NR (mitochondrial & anti-aging support): NMN: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-mononucleotide NR: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-riboside

Regenerative & Injection Therapies

PRP – Platelet-Rich Plasma: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990861/

Bone Marrow–Derived Stem Cells (BMAC): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630382/

Adipose-Derived Stem Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416130/

Amniotic / Placental Tissue Products: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124018/

Exosomes (cell signaling vesicles): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465611/

Ultrasound-Guided Injections: https://radiopaedia.org/articles/musculoskeletal-ultrasound-guided-injection

Needle Tenotomy (scar-tissue disruption): https://pubmed.ncbi.nlm.nih.gov/30428129/

Detox, Blood & Environmental Interventions

Sauna (heat detox & cardiovascular benefit): https://www.health.harvard.edu/staying-healthy/saunas-and-your-health

Binders – Modified Citrus Pectin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452227/

GI Detox / Toxin Binders (general concept): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/

Heavy Metal Chelation (DMPS concept): https://pubmed.ncbi.nlm.nih.gov/12198644/

Mercury Toxicity: https://www.cdc.gov/mercury/index.html

Microplastics in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068600/

EBOO Therapy (ozone-based blood filtration): https://pubmed.ncbi.nlm.nih.gov/36681461/

Therapeutic Plasma Exchange (TPE): https://www.ncbi.nlm.nih.gov/books/NBK557561/

INUSpheresis (advanced plasma filtration): https://pubmed.ncbi.nlm.nih.gov/37324197/

Medications & Drug Classes Mentioned

Corticosteroids (Prednisone – tendon risk): https://medlineplus.gov/druginfo/meds/a601102.html

Fluoroquinolone Antibiotics (tendon rupture risk): https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-fluoroquinolone-antibiotics

GLP-1 Agonists (Semaglutide / Tirzepatide / Retatrutide discussion): Semaglutide: https://pubmed.ncbi.nlm.nih.gov/36421543/ Tirzepatide: https://pubmed.ncbi.nlm.nih.gov/35220624/

Nutrition & Food-Related Mentions

Protein Intake & Muscle Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566799/

American Gluten vs European Wheat: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799814/

Seed Oils & Inflammation (discussion topic): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963/

Dairy & Inflammation (contextual mention): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122229/

Key Mechanisms & Concepts

Poor Blood Supply in Achilles Tendon (Watershed Zone): https://pubmed.ncbi.nlm.nih.gov/17021202/

Mitochondrial Dysfunction & Aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843959/

Stem Cells as "Medicinal Signaling Cells": https://pubmed.ncbi.nlm.nih.gov/25784997/

Show Notes

00:00 Introduction to Exosomes and Stem Cells

01:01 Dr. Morse's Background and Transition to Regenerative Medicine

02:03 Achilles Tendon Tears: Causes and Prevention

05:02 Preventative Measures and Treatments for Achilles Injuries

10:26 The Role of Nutrition in Tendon Health

12:53 Peptides and Their Impact on Tendon Health

15:50 Stem Cells: Misconceptions and Applications

20:52 Comparing Stem Cell Sources and Their Potency

29:52 The Controversy of International Stem Cell Treatments

34:04 Cleaning Toxins from Your Blood

34:19 The Toxic Burden in Our Environment

35:57 Practical Detox Methods

37:47 Mercury and Heavy Metal Testing

44:47 The Problem with American Gluten

46:49 Underrated Peptides for Health

53:42 Growth Hormone and Anti-Aging

01:03:34 Advanced Blood Cleaning Techniques

01:04:51 Conclusion and Contact Information

The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

(Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

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