UCSF stroke neurologist Dr. Anirudh Sreekrishnan and UCSF vascular neurosurgeon Dr. Luis Savastano describe Moyamoya disease, a rare condition where arteries at the base of the brain become narrowed or blocked, reducing blood flow. The name “moyamoya” means “puff of smoke” in Japanese, describing the tiny vessels that form to compensate. These fragile vessels can cause strokes or bleeding. Treatment often involves surgical procedures, such as direct or indirect revascularization, to restore blood flow and reduce stroke risk. Series: "UC San Francisco News" [Health and Medicine] [Show ID: 41036]

Experts present new tools for managing PSA-recurrent prostate cancer. Dr. Steven Seyedin describes how PET/CT imaging enhances detection by reducing false positives and improving staging accuracy. Dr. Thomas Hope highlights PSMA PET imaging, now the standard approach, which identifies cancer more precisely by targeting tumor-specific proteins. Dr. Julian Hong discusses stereotactic body radiation therapy (SBRT) for patients with limited metastases, showing that it offers effective, low-toxicity treatment while preserving quality of life. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40867]

Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]

Kimberly Peters, a stage four uterine cancer patient at UC San Diego Health, urges government leaders not to cut science funding. She warns that reduced federal support risks delaying vital research and life-saving cures. [Health and Medicine] [Show ID: 41071]

On his very first day at San Francisco General Hospital, Dr. Paul Volberding met his first AIDS patient – a moment that shaped his career and left an indelible mark on the fight against an epidemic. Now, more than 40 years later, Volberding reflects on the creation of Ward 86, the nation’s first HIV clinics, and how UCSF’s compassionate, community-first approach redefined HIV/AIDS care worldwide. The work of Volberding and UCSF’s dedicated clinicians and scientists laid the foundation for advancements that continue to save lives today. [Health and Medicine] [Show ID: 40986]

Experts from UCSF outline the latest treatments and research for advanced prostate cancer, highlighting improved outcomes and promising therapies. Dr. Kelly Fitzgerald reviews intensified androgen deprivation therapy (ADT) and the evolving role of imaging, triplet therapy, and local treatments. Dr. Ivan de Kouchkovsky shares how radioligand therapies like Lutetium-177 PSMA target cancer with precision and are now approved earlier in care. Dr. David Oh explains immunotherapy strategies, including cancer vaccines and checkpoint inhibitors, and explores new options like bispecific T-cell engagers. Dr. Terry Friedlander discusses bone health and the impact of hormone therapy, offering strategies to reduce fracture risk and improve quality of life. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40868]

As part of the 2025 Developmental Disabilities Conference, Dr. Elysa Marco talks about various biological approaches to therapy. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40623]

As part of the 2025 Developmental Disabilities Conference, Emily Hill talks about how sibling support can be a catalyst for family empowerment. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40622]

As part of the 2025 Developmental Disabilities Conference, Judy Mark, Vivian Do, Miguel Lugo, all from Disability Voices United, talk about supported decision-making in healthcare. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40611]

Urologic oncologist Dr. Peter Carroll presents the latest research on active surveillance as a preferred approach for managing low-risk prostate cancer and selected cases of intermediate-risk disease. Drawing from two decades of UCSF data, he explains how long-term outcomes support the safety and effectiveness of delaying treatment for carefully monitored patients. Carroll emphasizes that surveillance decisions should be guided by MRI imaging, PSA density, cancer volume, histologic subtype, and genomic testing. He notes that while many men experience gradual changes over time, only a small percentage require immediate treatment. Carroll also discusses innovations such as AI-assisted pathology and risk profiling to reduce unnecessary procedures. His data-driven approach offers patients a personalized path that preserves quality of life without compromising outcomes. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40801]