Cancer isn’t just random genetic mutations. It doesn’t “just happen.” In this episode, Dr. Connealy pulls back the curtain on what really drives cancer — from mitochondrial breakdown and hidden toxins to stress, parasites, and even low voltage inside your cells. You’ll learn how to hack your environment, strengthen your biology, and prevent disease years before a tumor ever shows up on a scan.

 Dr. Leigh Erin Connealy, MD, is one of the most sought-after integrative oncologists in the world. She runs the Cancer Center for Healing and the Center for New Medicine, where she’s been upgrading patient outcomes for nearly four decades. Her new book, The Cancer Revolution, gives you the tools to take back control of your biology and stop cancer before it starts.

What You’ll Discover

• 🔋 Cell Voltage = Healing: Why -25 millivolts is the magic number for your cells.
• 🧬 Cancer Is Metabolic: Otto Warburg was right — it’s about broken energy systems, not just genes.
• 😱 The Stress Factor: Why unresolved emotional trauma shows up in cancer cases again and again.
• 🍄 Fungus & Parasites: How overlooked infections hijack your immune system and fuel tumor growth.
• 🌱 Lifestyle Hacks That Work: Daily detox, deep sleep, organic nutrition, and movement as cancer prevention.
• 🧘 The Missing Piece: Why your emotional and spiritual state matters as much as your labs.

Why Listen
If you’ve ever wondered how to bulletproof yourself against cancer — or how to shift your biology if you’ve already faced it — this is the roadmap. Dr. Connealy combines cutting-edge science, holistic healing, and decades of patient results into one conversation that could literally save lives.

Resources & Links

• https://www.connealymd.com/

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What if one natural molecule could reverse key signs of aging, repair your immune system, grow your hair, and even help you sleep better?

In this episode, Robert Lufkin, MD, sits down with Leslie Kenny, a patient advocate with a remarkable story. At 39, she was told she had only 5 years to live with lupus and rheumatoid arthritis. Instead, through lifestyle changes and a breakthrough discovery about spermidine, she now enjoys extraordinary health — with a biological age of just 21 at age 60.

👉 You’ll learn:

• What spermidine is and why it’s overlooked in longevity research
• How it activates autophagy, mitophagy, and immune rejuvenation without muscle loss
• The difference between food-derived vs. synthetic spermidine (and why it matters)
• Surprising external signs it’s working: hair growth, stronger nails, clearer skin, and better sleep
• Why this molecule hits 9 of the 12 hallmarks of aging and may be the safest, most effective longevity tool available

This is the anti-aging molecule Big Pharma can’t patent — but you need to know about it.

🔗 Links & Resources Mentioned

• Leslie’s work: Oxford Healthspan (Instagram: @oxfordhealthspan)
• Oxford Longevity Project: @oxfordlongevityproject
• Leslie’s Patient Advocacy: @lesliesnewprime

 Get 15% off your first purchase with code ROBERTLUFKINMD or via this link: https://oxford-healthspan.myshopify.com/RobertLufkinMD 

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Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair.

This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available in their program. I am an advisor to Gatlan but I only advise companies that I believe in and would use for myself and my family. 

The conversation uncovers the remarkable story behind rapamycin's discovery - how it sat forgotten in a researcher's freezer for years before its life-extending properties were recognized. Dr. Rick explains that mTOR has been conserved through billions of years of evolution precisely because it's so critical to survival, sensing nutrient availability and telling cells whether to grow or repair themselves.

What makes this discussion particularly valuable is Dr. Rick's practical approach to using rapamycin as a metabolic health tool rather than a miracle drug. He shares insights on proper dosing strategies, emphasizing the importance of cycling between periods of mTOR suppression and activation to mimic natural patterns our bodies evolved with. This cycling approach - perhaps taking rapamycin for a few months, then taking a month off for anabolic growth through strength training - may be key to optimizing its benefits.

The breadth of rapamycin's benefits is truly remarkable - from hair regrowth and skin rejuvenation to improvements in hearing, fertility, and protection against diseases ranging from Alzheimer's to atherosclerosis. This suggests rapamycin isn't just treating symptoms but addressing a fundamental mechanism of aging itself.

Ready to understand how this single pathway could influence every aspect of how we age? Listen now to discover why balancing growth and repair cycles might be the key to extending your healthspan and potentially your healthspan and potentially your lifespan.

https://www.gatlan.com/

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What if the key to feeling better at 45 than you did at 25 isn't about accepting "normal" lab values, but about optimizing your hormones to their ideal levels? In this eye-opening conversation, Dr. Lauren Fitzgerald—a board-certified anesthesiologist who now specializes in bioidentical hormone replacement therapy—challenges conventional medical wisdom about hormone health.

Dr. Fitzgerald breaks down the critical difference between bioidentical hormones and non-bioidentical versions. This distinction isn't just academic—it has profound implications for safety and effectiveness. While your doctor might tell you your hormone levels are "normal," those ranges often represent the average of an increasingly unhealthy population, not optimal levels for vitality and longevity.

Contrary to lingering misconceptions from outdated studies, bioidentical hormone replacement therapy has been shown to decrease cancer risk, protect cardiovascular health, prevent osteoporosis, and support cognitive function. For both women navigating perimenopause and men experiencing age-related testosterone decline, properly administered bioidentical hormones can transform quality of life. 

Whether you're struggling with brain fog, fatigue, weight issues, or just don't feel like your vibrant self anymore, this conversation offers a roadmap to reclaiming your energy and zest for life through evidence-based hormone optimization.

https://larimarmed.com/.  @worldlink

https://worldlinkmedical.com/education/conferences/academic-summit-2025

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Unlock the secrets of male well-being with Christos Konstantinidis, the pioneering founder and CEO of Adam Health, as we unveil the profound link between erectile health and holistic male wellness. Discover how your body's signals, often overlooked, could be the earliest indicators of serious health concerns like cardiovascular disease. Christos provides enlightening insights into how erectile function serves as a critical health barometer, cutting across cardiovascular, neurological, and hormonal domains.

Explore the natural phenomena of nighttime erections and their vital role in sustaining erectile health, as well as the promise held by erectile dysfunction drugs in potentially extending lifespan and reducing the risk of chronic illnesses such as Alzheimer's. With Christos's expert guidance, learn about groundbreaking tools like Adam Health's erection health tracker, designed to empower men in managing their sexual health proactively. Don't miss out on the array of solutions available to tackle erectile issues, from PDE5 inhibitors to cutting-edge rejuvenation treatments, all aimed at improving quality of life and fostering an open dialogue about men's health.

https://talktoadam.com

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What if we could reset our cellular batteries? In this fascinating deep dive into cutting-edge longevity science, Tom Benson from Mitrix Bio reveals how mitochondrial transplantation could revolutionize how we treat age-related diseases and potentially add decades of healthy living to our lives.

The conversation begins by exploring the extraordinary nature of mitochondria – those tiny power plants within our cells that generate 95% of our body's energy through molecular rotors functioning like miniature jet turbines. With approximately a quadrillion mitochondria comprising 10% of our body weight, these ancient organelles trace back to a symbiotic merger with our cellular ancestors over a billion years ago.

Unlike the nuclear DNA we inherit from both parents, our mitochondrial DNA comes almost exclusively from our mothers, creating fascinating maternal lineage patterns where thousands of family members share identical mitochondrial DNA. As we age, this mitochondrial DNA gradually accumulates damage, with factors like stress, smoking, and medical treatments accelerating deterioration. By our 90s, this decline reaches a critical threshold that appears to drive much of the aging process.

The most exciting revelation comes in learning that mitochondria naturally move between cells in our bodies – and scientists are now leveraging this phenomenon through transplantation techniques. By harvesting mitochondria from stem cells grown in bioreactors and reinjecting them, researchers are seeing remarkable improvements in cognition, strength, and immune function in aged mice, essentially restoring youthful cellular energy levels. Human trials are already underway, though still at small scale.

For anyone fascinated by the frontiers of longevity science and the quest to not just add years to life, but life to those years, this conversation offers a glimpse into one of the most promising approaches emerging today. 

https://mitrix.bio/

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Curious about the real power of testosterone beyond the realm of bodybuilding? Join us as we sit down with Dr Andrew Sun, a fellowship-trained andrology specialist, who unpacks the diverse roles this crucial hormone plays in men's health. Discover the surprising factors, like poor sleep and metabolic syndrome, that can lower testosterone levels even in younger men. Andrew guides us through the significance of testosterone replacement therapy, not as a vanity metric but as a doorway to enhancing overall health and longevity.

This episode is sponsored by Gatlan who makes the new oral testosterone called Kyzatrex that we will be discussing available in their program. I am an advisor to Gatlan but I only advise companies that I believe in and would use for myself and my family. 

Ready to navigate the complex world of testosterone therapy? We explore the pros and cons of various treatment methods, with a focus on injection challenges such as hormone fluctuations, potential side effects, and fertility concerns. Andrew shares his expert insights on long-term treatment commitments and strategic side effect management, like regular blood donations to tackle increased red blood cell production. We also discuss the importance of personalization in therapy, ensuring dose and frequency adjustments are tailored for optimal patient outcomes.

Innovation takes center stage as we explore Kyzatrex, a promising oral testosterone therapy that aligns with natural circadian rhythms. Andrew reveals how this treatment minimizes traditional side effects seen with other testosterone delivery methods. Whether you're considering therapy or just curious about the latest advancements, this episode offers a comprehensive look at how testosterone innovation is reshaping men's health for the better.

https://www.upnt.com/physicians/md-andrew-sun/

 https://www.gatlan.com/

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Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
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Ever wondered if you can truly turn back the clock on aging? Join us in this compelling episode as Dr. Mark Hyman shares his extraordinary insights on the power of functional medicine to rejuvenate the body and mind at any age. Discover how Dr. Hyman's personal and professional journey led him to uncover the foundational causes of aging and chronic disease, and learn about the vital distinctions between beneficial and harmful stress. We also delve into the fascinating concept of biological versus chronological aging and the transformative potential of lifestyle choices in reversing biological age.

This episode is sponsored by Rio.life. I am an advisor to Rio but I only advise companies that I believe in and would use for myself and my family. 

Our discussion takes a critical look at the current healthcare and medical education systems, shedding light on how profit-driven motives can undermine simple, effective treatments. Dr. Hyman introduces the concept of hormesis, explaining how small, beneficial stresses like intermittent fasting, cold showers, and saunas can activate the body's innate healing mechanisms. We underscore the crucial role of modern nutritional science in medical education, arguing for a more integrated approach that places lifestyle and diet at the core of health management.

In our final deep dive, we explore the complex relationship between aging, inflammation, and nutrition. Dr. Hyman discusses the hallmarks of aging and the importance of balancing what the body has too much of and what it lacks. This includes the impact of refined oils versus traditional oils, the benefits of higher protein intake for older adults, and the emerging technology of continuous glucose monitors. We also touch on the profound influence of social connections on health and longevity.

https://www.functionhealth.com/.         https://www.rio.life/

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This week we are broadcasting a fascinating presentation from my good friend Dr Vincent Giampapa where he discusses the potential and actual use of stem cell therapy for longevity. I have had the pleasure of visiting his remarkable longevity center in San Jose Costa Rica. We will be having a dedicated upcoming episode about it. 

This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it! https://www.raadfest.com/

Prepare to be captivated by the insights of Dr. Vincent C. Giampappa, a trailblazer in anti-aging medicine and technology, as we uncover the secrets behind the rapid advancements in this field. With aging-related knowledge doubling every three months, Vince emphasizes the urgency of maintaining good health to fully benefit from these breakthroughs. We explore the compelling concept of biological clocks within the human body, from the central aging clock in the hypothalamus to peripheral clocks in stem and somatic cells, and how our lifestyles and genetics can influence these pivotal systems.

In a thought-provoking discussion, we delve into emerging therapies in aging medicine, focusing on the regenerative power of the body's stem cells. Vince unveils promising therapies like umbilical cord stem cell infusions and gene-enhanced stem cell functions, potentially restoring lost functions and extending our healthspan. We also dive into the groundbreaking world of gene therapy techniques, including viral vectors, plasmids, and even the potential of creating artificial chromosomes, all paving the way for revolutionary therapeutic strategies in combating aging.

As we venture into the future of stem cell therapy, we explore the concept of "bioinsurance" and the transformative impact of AI and quantum computing on medical research. Imagine a world where you can bank your stem cells for future use, slowing the aging process and enhancing overall health. We conclude with the empowering notion of personalized therapies, where you can actively choose your path in the realm of anti-aging and regenerative medicine. Tune in to discover how these advancements promise to redefine our understanding of aging and renew our vision of maintaining independence and vitality throughout life.

https://drgiampapa.org/      https://www.rmihealth.com/.  https://www.raadf

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As we near the end of the school year, I'd like to give a shoutout to Mr George Gaskin's 7th grade history class at Harvard-Westlake School who are fans of this program. 

Have you ever wondered what keeps your cells functioning properly? The answer might be a molecule with a funny name but serious implications for longevity. Spermidine, found in every living cell on Earth, is essential for triggering autophagy—your body's internal cleaning system that recycles damaged cellular components.

Biochemist Dr. Melissa Cano takes us deep into the fascinating world of cellular metabolism, explaining how this small but mighty molecule could be key to healthier aging. Our spermidine levels naturally decline as we age, precisely when we need its protective effects most. This decline happens through three pathways: diminished internal production, changes in gut microbiome, and potentially decreased absorption from food—creating a perfect storm for cellular aging.

What makes this conversation particularly compelling is the growing body of evidence supporting spermidine's role in longevity. Epidemiological studies show people with higher dietary spermidine intake live 5-10 years longer on average. In lab studies, supplementation extends lifespan in multiple organisms by 5-20%. A groundbreaking 2024 study in Nature Cell Biology even revealed that spermidine mediates many of fasting's benefits—suggesting this molecule could be a natural caloric restriction mimetic without the hunger.

Whether you're already familiar with longevity compounds like rapamycin and metformin or just beginning your healthy aging journey, this episode offers practical insights for everyone.  Ready to support your body's natural cleaning and rejuvenation processes? Learn how this remarkable molecule works at the cellular level and discover if spermidine supplementation might be the missing piece in your longevity strategy.

This episode is sponsored by SpermidineLife whose products are mentioned in the program.  Use promo code ROB15 for discount. 

https://spermidinelife.us/products/spermidinelife-extra-dietary-supplement?utm_source=Lufkin&utm_medium=podcast

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Complete Metabolic Heart Scan (LUFKIN20 for 20% off) https://www.innerscopic.com/
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