Cravings aren’t just about weak will; they’re biology doing exactly what billions of food dollars engineered them to do. We sit down with Sander Brus to unpack how sweetness hijacks reward circuits, why kids are showing up with adult metabolic diseases, and what happens when you flip the switch on sweet taste itself.

Sander takes us from his diagnostics background into the heart of metabolic health, explaining how sweet taste receptors (T1R2/T1R3) live on the tongue and in the gut, where they act as glucose sensors. You’ll hear how plant compounds like gymnemic acids can temporarily block those receptors, making soda taste like “nothing,” softening the dopamine surge, and even reducing post-meal glucose and insulin in some studies. We compare the behavioral punch of reducing perceived sweetness to the pharmacology of GLP‑1 agonists, and we dig into CGM experiments that show real-world spikes shrinking when sweetness is inhibited.

We also zoom out to the food environment: why sugar is uniquely craved compared to seed oils or grains, how high fructose corn syrup supercharges palatability, and why noncaloric sweeteners may still nudge insulin through cephalic responses. Sander shares practical playbooks for using a mouth rinse to tame dessert triggers or a capsule 30 minutes before carb-heavy meals to blunt spikes. Along the way, we talk palate reset in 10–14 days, metabolic flexibility, insulin’s role in aging pathways like mTOR, and the hope of nudging an industry to build foods that support healthspan rather than erode it.

If you’ve ever wanted fewer cravings, steadier energy, and data-backed ways to quiet the glucose roller coaster, this conversation offers both science and tactics you can try today. Listen, share with someone navigating sugar struggles, and tell us your biggest craving scenario so we can tackle it in a future episode. And if you’re finding value here, subscribe, leave a review, and help more people discover metabolic tools that actually work.

https://nosuhealth.com/

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What if the real action in cancer isn’t in the genome, but upstream in the mitochondria and the metabolic “terrain” that shapes every signal your cells send and receive? We sit down with Dr Nasha Winters to rethink cancer as an ecologic disease and explore how shifting the terrain can change outcomes without rejecting standard care.

We dig into why ketones are more than fuel. Nasha explains how a therapeutic ketotic state—reached through fasting, carb restriction, or exogenous support—can lower inflammatory cytokines, dial down insulin and IGF-1, reduce angiogenic drive, and directly influence the vagus nerve to move the body into a healing state. You’ll hear practical ways to pair ketosis with radiation, hyperbaric oxygen, and hyperthermia to both enhance efficacy and protect healthy tissue, plus real markers to track progress, from GKI and CRP to LDH and organic acids.

Skeptical about “alternative” claims? So is Nasha—until the data line up. We talk pharmacogenomics, validated drug-sensitivity testing, and the smart use of repurposed meds like metformin, low-dose naltrexone, and mebendazole when the biology says they fit. We also connect longevity and cancer prevention through mitochondrial health: strategic fasting, urolithin A, melatonin, vitamin D, circadian repair, and toxin reduction all play a role in building metabolic flexibility. To close, Nasha unveils her vision for a residential, integrative hospital and research institute on a regenerative farm, where tumor experts and terrain experts co-manage under one roof—data first, dogma last.

If this conversation expanded your map of what’s possible in oncology and longevity, follow the show, share it with someone who needs options, and leave a review with the biggest insight you’re taking into your own care.

https://drnasha.com/

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Imagine your brain as a world-building engine that never shows you the thing-in-itself, only a model tuned for survival. Now imagine a molecule that doesn’t just bend that model but switches it to a fully formed, hyper-detailed reality populated by entities that seem to think, act, and sometimes deny you entry. That’s the claim at the heart of our conversation with computational neurobiologist and DMT researcher Andrew Gallimore, author of Death by Astonishment.

We start by laying the groundwork: predictive brains, interface theory, and why ordinary dreams and hallucinations reuse what the brain already knows. From there we compare classic psychedelics—LSD, psilocybin, mescaline—with DMT. The former loosen constraints; the latter appears to replace the entire world model. Reports converge on crystalline clarity, higher-dimensional geometry, and interactive beings that feel autonomous. Andrew introduces the “lockout” effect, where access can be refused, and argues that orthodox neuroscience struggles to explain structured, agent-like phenomena arising so quickly and coherently.

The breakthrough comes with extended-state DMT using target-controlled infusion—a medical technique borrowed from anesthesia—to hold explorers in the space for 30 to 90 minutes or longer. Early pilots suggest the state stabilizes, enabling intentional interaction and systematic observation. We explore a research roadmap: send in mathematicians to probe topology, linguists to parse symbolism, anthropologists to map social rules, artists to render lawful structure. Instead of asking entities to prove themselves, we let experts recognize operations that exceed typical human cognition, like effortless four-color theorem tilings or impossible geometric transforms performed in real time.

We also talk safety, differences between DMT, ayahuasca, and 5-MeO, and emerging retreat-and-research models that combine medical oversight with rigorous protocols. Whether DMT reveals autonomous minds, emergent intelligence, or a yet-unknown information source, extended-state studies could convert private revelation into public evidence. Subscribe, share with a curious friend, and leave a review with the question you’d ask if you had an hour in the DMT space. What test would convince you that contact is real?

https://noonautics.org/

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A facelift without a telltale ear scar sounds like sci‑fi—until you hear how Dr. Mark Mani designed it. We sit down with the Beverly Hills surgeon, artist, and inventor to explore how endoscopic deep‑plane lifting repositions the face where gravity actually acts, delivering natural contour without the stigma of visible incisions. Mark traces the decade it took to refine the approach, publish the first academic description, and train surgeons worldwide, and he explains why subtle, anatomically honest work beats skin‑tension shortcuts every time.

That precision sits inside a larger philosophy. Mark’s childhood bridged Indian and American worlds, his studies spanned Harvard to Baylor, and his curiosity leaps from quantum theory to biology. He argues that humans cooperate far beyond what selfish‑gene logic predicts because we chase legacy—phenotypic immortality—through service, craft, and knowledge. That belief shows up in his operating room and his volunteer work with Face Forward International, where reconstructive surgery helps survivors of burns and abuse reclaim identity and voice. Beauty, in this frame, is not an algorithm; it’s dignity, agency, and the confidence to meet another person’s gaze.

We also challenge a big myth: you can fill your way to youth. Mark makes the case for conservative strategy, fat over filler when volume is needed, and why overfilling often makes faces look bigger, not younger. Then we shift to recovery and daily life with the Mani Flow, his travel‑ready neck wearable that supports back sleeping, protects facial ligaments, and turns red‑eyes into real rest. If you care about natural results, subtle scars (or none), and the future of endoscopic facelifts, you’ll find clear takeaways, practical nuance, and a humane way to think about aging and aesthetics.

If this conversation sparked ideas, follow and share the show, leave a quick review, and tell us: what’s one mindset shift that changed how you see aging?

https://marcmani.com/

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A world champion athlete shouldn’t have to fight for the right diagnosis—yet Kelly Palace did, for years. What began as a swimmer’s quick fix for itchy, chlorine-dry skin became a descent into topical steroid addiction and withdrawal: spreading rashes, burning, oozing skin, misdiagnoses, and the long, lonely road of recovery. Kelly lays out the unvarnished truth about a “miracle cream” millions use and why the industry’s strongest selling points—fast relief and flawless skin—can mask a deeper problem that grows with every tube and refill.

We walk through the real mechanism under the surface: the blanching test that validated potency, the escalation from mild to super-potent products, and tachyphylaxis that drives dependency. Kelly explains how withdrawal can look nothing like classic eczema, why infants and facial skin absorb more, and how short, tightly defined courses can be appropriate for acute flares—while chronic use becomes a trap. Her journey to Dr. Marvin Rappaport’s work, the co-founding of ITSAN (International Topical Steroid Awareness Network), and the movement to push medicine to recognize topical steroid withdrawal provide a roadmap for patients seeking answers when standard care fails.

This is also a practical guide. You’ll hear the questions to ask before filling a prescription, the difference between treating symptoms and addressing root causes, and the lifestyle foundations—sleep, hydration, nutrition, stress reduction, gentle barrier care—that help the skin do its job. Kelly makes a compelling case to treat the skin like the longevity organ it is and to choose what you apply as carefully as what you eat. The human side matters too: the isolation, the mental health toll, and the hope that comes with recognizing the pattern and finding support.

If you or someone you love uses hydrocortisone, triamcinolone, or other topical steroids, this conversation will change how you think about risk, duration, and informed consent. Subscribe, share this episode with a friend or clinician who needs to hear it, and leave a review with your questions—what would you ask your doctor about your skin routine?

https://www.kellypalace.com/       

https://www.itsan.org/

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What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible.

During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways, cellular cleanup mechanisms, and metabolic efficiency programs that can extend lifespan in virtually every organism studied.

The breakthrough came when Dr. Rhodes identified four specific metabolites that appear in human blood during a 36-hour fast. When combined and given to C. elegans worms, these compounds extended their lifespan by a staggering 96% - essentially doubling how long they lived.

This led to the creation of Mimio Health, a company developing supplements that recreate the molecular environment of fasting. Clinical studies show these supplements can maintain an anti-inflammatory state and cardioprotective benefits even while eating regular meals. Even more remarkably, eight weeks of supplementation reduced biological age by 2.5 years, increased free testosterone by 50%, and improved cholesterol profiles and glucose regulation. I am an advisor to Mimio Health, but I only work with companies that are based on solid science with a strong potential to help humanity.

Throughout our conversation, Dr. Rhodes offers thought-provoking insights about how modern eating patterns create chronic inflammation and how our bodies evolved with natural fasting cycles. He argues that constant eating without fasting windows may actually be the unnatural state for human metabolism - not the other way around.

Whether you're interested in longevity, metabolic health, or simply understanding how our bodies respond to food, this episode offers a compelling look at cutting-edge nutritional biochemistry that could change how we approach health optimization. Ready to discover how your body might already possess the blueprint for extraordinary health and longevity? Listen now and learn how to activate it.

Mimio Health (LUFKIN for 15% off) https://mimiohealth.sjv.io/c/5810114/2745519/30611

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What if the clothes you wear and the sheets you sleep on could actively improve your health without you doing a thing? In this fascinating conversation, Seth Casden introduces us to a truly passive biohacking tool that's hiding in plain sight.

Technology transforms ordinary fabrics into wellness tools by embedding them with micron-sized minerals that capture body heat and convert it into beneficial infrared light. This light penetrates the skin and increases local circulation, delivering more oxygen to cells and tissues. The beauty lies in its simplicity—no additional effort required, no lifestyle changes needed.

"We're converting heat energy into light energy," Casden explains, describing how the minerals in these fabrics absorb the 100+ watts of heat constantly emitting from our bodies and return it as infrared light. Clinical studies show this process increases tissue oxygenation by about 8% after just 90 minutes of wear.

Unlike many wellness technologies that require dedicated time or effort, the fabric works invisibly throughout your day in clothing and bedding. Whether you're exercising, working, or sleeping, the technology continuously improves circulation—the fundamental mechanism behind numerous health benefits from enhanced recovery to better temperature regulation.

For athletes, the technology offers particular advantages. "You wear it while competing and then after the race to recover as fast as you can," Casden shares from his own experience as a triathlete. Elite sports teams, Olympic athletes, and figures like Tom Brady have already embraced the technology for its performance benefits.

Ready to try this effortless biohack? Casden recommends starting with either socks (if you're on your feet all day) or pillows (to potentially enhance sleep quality and brain health). With partners including Under Armour, KT Tape, and various bedding companies, Celliant products are increasingly accessible to anyone looking to optimize their wellness without adding complexity to their lives.

Curious about this technology that works while you simply live your life? Listen now and discover why improved circulation might be the simplest path to better performance, faster recovery, and enhanced wellbeing.

https://celliant.com/.   https://shopcelliant.com/

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What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death.

Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how these organelles became integrated into our cells over evolutionary history. "Mitochondria used to be bacteria that entered into the cell and formed this symbiosis," she explains, describing how this evolutionary leap enabled life to thrive in oxygen-rich environments. This bacterial heritage gives mitochondria unique properties, including their own DNA separate from our nuclear genome, which makes them both vulnerable to damage and potentially replaceable.

The revolutionary approach Minovia has pioneered involves harvesting a patient's own stem cells, enriching them with young, healthy mitochondria from donor sources like placentas, and returning these energized cells to the patient. Unlike direct mitochondrial infusions, which pose risks of immune rejection, this method has shown remarkable safety and efficacy in clinical trials for both rare pediatric diseases and age-related conditions. "Seeing a child six and a half years old in a baby stroller and then two months later he's running in a shopping mall—it's unbelievable to see the impact," Dr. Yivgi-Ohana shares.

Perhaps most surprising is the current lack of clinical testing for mitochondrial function, despite its crucial role in health. "The strongest signal for health is how well mitochondria are doing," Dr. Yivgi-Ohana emphasizes, predicting that within a decade, mitochondrial function testing will become as routine as checking hemoglobin levels. This could transform preventive medicine by identifying mitochondrial dysfunction before symptoms appear.

Explore this frontier of cellular medicine that targets both mitochondrial and immune dysfunction—two major hallmarks of aging—simultaneously. Could rejuvenating our cellular batteries be the key to extending healthy lifespan? Listen now to discover how mitochondrial science is revolutionizing our understanding of aging and disease.

https://minoviatx.com/

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Ever wondered how a single molecule can regulate blood flow, support neurotransmission, and boost immune defense? Dr. Bryan unravels these mysteries and cuts through the confusion with nitrous oxide, sharing invaluable insights from his collaborations with Nobel Prize winners. Join us as we explore why nitric oxide is pivotal to our health and longevity, and why it deserves more attention in medical circles.

We also probe into the darker side of proton pump inhibitors (PPIs) and their detrimental effects on nitric oxide production. Through Dr. Bryan's expert lens, we examine the serious health risks tied to long-term PPI use, such as heart disease and cognitive decline, and highlight the hidden dangers of fructose metabolism in suppressing nitric oxide synthase. Our discussion underscores the importance of understanding these complex interactions and the need for increased awareness among both medical professionals and patients.

Not stopping there, we venture into the fascinating interplay between erectile dysfunction drugs and nitric oxide. Dr. Bryan explains how maintaining optimal nitric oxide levels can enhance the effectiveness of medications like Viagra and Cialis, with potential benefits for overall vascular health and longevity. We wrap up with practical advice for boosting nitric oxide naturally, including simple lifestyle changes and mindfulness around oral health products. Don't miss out on this opportunity to enrich your understanding and take proactive steps toward better health!

https://n1o1.com

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GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management.

When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from colleagues who expected a naturopathic doctor to reject pharmaceutical interventions, she couldn't ignore the compelling evidence. What she found most remarkable was how these peptides—which naturally occur in our bodies—could address multiple health issues simultaneously through their "pleiotropic" effects.

The conversation ventures into territory rarely discussed in mainstream medical circles: how lower, personalized doses might provide optimal benefits while minimizing side effects. Dr. Tina shares striking clinical observations, including her own experience with Hashimoto's thyroiditis improving dramatically on a micro-dose regimen. Patients report unexpected improvements in conditions ranging from rheumatoid arthritis to depression to addictive behaviors—benefits that appear independent of weight loss.

Most fascinating is Dr. Tina's perspective on dosing strategy. While conventional protocols typically start higher and escalate quickly, this approach risks receptor desensitization and excessive AMPK pathway activation, potentially causing disproportionate muscle loss. She advocates for "slow and low" dosing, tailored to individual needs, working alongside comprehensive lifestyle changes.

The discussion also tackles accessibility issues, comparing compounded options with brand-name medications, and speculates about future developments that might make these treatments more affordable and personalized. If you're curious about metabolic health, inflammation, or the future of medicine, this conversation offers a refreshingly nuanced perspective that cuts through polarized debates with evidence-based insights.

https://www.drtyna.com/

https://www.gatlan.com/

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