Late last year, the CSIS Commission on Strengthening America's Health Security released its final report on ending the cycle of crisis and complacency in U.S. global health security. This miniseries of Take as Directed will delve into the detail of some of the Commission's recommendations. In this first episode of the miniseries, Steve talks with Dr. Richard Hatchett, CEO of Coalition for Epidemic Preparedness Innovations (CEPI). CEPI is a new model of partnership to finance and co-ordinate the development of technologies against high priority public health threats and emerging infectious diseases with pandemic or epidemic potential. Richard and Steve discuss the report's recommendation to systematically confront two urgent technology challenges: the need for new vaccines and therapeutics; and the public health communications crisis.