Episode Summary:This episode discusses telomeres and aging. Is it the fountain of youth?Topics discussed are the following:Telomeres—what are they?Telomeres and the aging processClinical studies on telomeres and human healthPotential ways to limit telomere shorteningFuture outlook and summaryEpisode References:Discovery of the structure of telomerase: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223129/ Nobel prize for the discovery of telomerase: https://www.nobelprize.org/prizes/medicine/2009/press-release/Telomeres shorten as we age: http://www.telomer.com.tr/wp-content/uploads/2015/12/TL_in_the_new_born_AvivA_IPRF_2001.pdfLandmark paper on telomeres and aging: http://science.sciencemag.org/content/279/5349/349Paper showing no effect with diet on telomere length: https://www.karger.com/Article/FullText/486586Cycloastragenol activates telomerase: https://www.karger.com/Article/Pdf/365290Hibernation concept applied to human health: https://www.ncbi.nlm.nih.gov/pubmed/30347515

Episode Summary:Kombucha—science and details—is the topic of this episode.Topics discussed are the following:Introduction to KombuchaHow to make KombuchaKombucha Benefits and scientific reviewPotential dangers/problems with KombuchaFuture outlook/opportunities for KombuchaEpisode References:2003 paper on Kombucha in the scientific literature: https://reader.elsevier.com/reader/sd/pii/S1047279718307385?token=D8F54D348F5FCE9EE5EA8310FD1984221D79EF0D74F81BDC1F6DEA856D311F2CD083222A79959CE249F120D6010143CA 2019 paper on Kombucha in the scientific literature: https://www.ncbi.nlm.nih.gov/pubmed/7476846 Adverse event surrounding kombucha: https://www.ncbi.nlm.nih.gov/pubmed/29197835Paper showing kombucha can be made using reishi mushroom: https://www.ncbi.nlm.nih.gov/pubmed/29717669Kombucha and skin health: https://www.ncbi.nlm.nih.gov/pubmed/29152918

Episode Summary:This episode chronicles the discovery, current science and mode of action of omega-3 fatty acids—along with what to look for in an omega-3 supplement. Topics discussed are the following:Discovery of omega-3 fatty acidsHealth benefits of omega-3 from the scientific literatureOmega-3 deficiency in the dietMode of action of omega-3What to look for in an omega-3 supplementEpisode References:Paper in the Lancet recounting the initial discovery of omega-3 fatty acids in Greenland Eskimos: https://www.ncbi.nlm.nih.gov/pubmed/89498 Study regarding omega-3 and IQ: https://journals.sagepub.com/doi/abs/10.1177/1745691612462585Omega-3 can slow rates of brain atrophy: https://www.ncbi.nlm.nih.gov/pubmed/25877495 Cancer protective effects of omega-3: https://www.ncbi.nlm.nih.gov/pubmed/23919748Omega-3 and depression: https://www.ncbi.nlm.nih.gov/pubmed/27103682 Omega-3 and Vision: https://www.health.harvard.edu/heart-health/omega-3-for-your-eyesResolvins and their role in the resolution of inflammation: https://www.ncbi.nlm.nih.gov/pubmed/25052386America Heart Association recommendation for omega-3 intake: https://www.ncbi.nlm.nih.gov/pubmed/24694001

Episode Summary:This episode tackles the following question— is taking a multivitamin essential for health or essentially a waste of money?Topics discussed are the following:Multivitamin—the iconic supplementScientific research regarding the efficacy of a multivitaminTakeaways from the researchSummary and recommendationEpisode References:See here for a historical review on how the term vitamin came about: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/vitamin-b-complex.html   List of Nobel prizes related to vitamin research: https://www.nobelprize.org/prizes/themes/the-nobel-prize-and-the-discovery-of-vitamins-2/  2009 multivitamin study on 161,808 postmenopausal women: https://www.ncbi.nlm.nih.gov/pubmed/192042212013 multivitamin study on 27,658 participants: https://www.ncbi.nlm.nih.gov/pubmed/192042212013 multivitamin study on 5,947 male physicians: https://www.ncbi.nlm.nih.gov/pubmed/244902652014 multivitamin paper by the US Preventative Services Task Force: https://www.ncbi.nlm.nih.gov/pubmed/245664742014 editorial on multivitamin use: http://annals.org/aim/fullarticle/1789253/enough-enough-stop-wasting-money-vitamin-mineral-supplements

Episode Summary:Discussed in this episode is the science behind the alkaline water craze and the perhaps unknown new area of hydrogen-infused water.Topics mentioned are as follows:pH: Introduction Acidification of the environment Alkaline Water: IntroductionScientific research surrounding alkaline waterScientific research around hydrogen waterSummary and takeawaysEpisode References:Alkaline water and reduction of cardiovascular risk in postmenopausal women: https://www.ncbi.nlm.nih.gov/pubmed/15113945  Alkaline water and bone health in postmenopausal women: https://www.ncbi.nlm.nih.gov/pubmed/15877873  Alkaline water and its support in those with gastric reflux: https://www.ncbi.nlm.nih.gov/pubmed/22844861Antioxidant properties of hydrogen water: https://www.ncbi.nlm.nih.gov/pubmed/17486089Health supporting properties of hydrogen water in those with metabolic syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831093/Hydrogen water and cognitive function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872234/Hydrogen water and gastric health: https://www.ncbi.nlm.nih.gov/pubmed/24589018

Episode Summary:This episode breaks down the cognitive health crisis affecting the world today and provides actionable information on how to promote cognitive health.Topics mentioned are as follows:The cognitive health crisisCombatting this cognitive health crisis using the three pillars of health (nutrition, exercise, and supplementation) Dr. Dan’s cognitive health formulaEpisode References:See here for a the paper mentioned on the power of the placebo effect: http://stm.sciencemag.org/content/6/218/218ra5See here for one paper on type 3 diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/pdf/dst-02-1101.pdf Regarding antidepressant use: https://www.pharmacist.com/article/many-people-taking-antidepressants-discover-they-cannot-quitL-Theanine supporting the stress response: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728665/Bacopa monnieri and cognitive performance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153866/pdf/acm.2008.0018.pdfAshwaghanda and supporting stress and anxiety: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270108/pdf/acm.2014.0177.pdfNatural products like magnolol and honokiol and their ability to attenuate stress and anxiety: https://pubs.acs.org/doi/10.1021/np9702446

Episode Summary:This episode discusses if there is credible science behind the celery juice craze sweeping the world on social media.Topics mentioned are as follows:Nutritional components of celeryPhytonutrients—the missing link to celery health benefits?Peer-reviewed science on celery juice Scientific takeaway and summaryEpisode References:See here for Instagram hashtags on celery juice and celery juice benefits: https://www.instagram.com/explore/tags/celeryjuice/ , https://www.instagram.com/explore/tags/celeryjuicebenefits/Read here about polyacetylene phytonutrients in celery: https://pubs.acs.org/doi/pdf/10.1021/jf048041s Paper regarding the potentially dangerous allergenicity of celery: https://www.sciencedirect.com/science/article/pii/S009167490047483XBioactive poverties of falcarinol: https://pubs.rsc.org/en/content/articlehtml/2017/fo/c7fo00110jChanges in amounts of celery bioactive depending on storage conditions: http://findresearcher.sdu.dk/portal/files/118232389/Recent_Patents_on_Food_Nutrition_Agriculture_2011_3_64_77.pdfSee here for the one paper in the peer reviewed literature on celery juice: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254272/

Episode Summary:This episode discusses the concept of how the expression of our genes controls our destiny for good metabolic health and how to change that fortune in our favor. Topics mentioned are as follows:Introduction to genes and gene expressionThe expression of our genes can become brokenDr. Dan’s gene expression formula Episode References:For a review on the vast amount of genetic information the body: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705322/Offspring of overweight men more prone to obesity: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00571-9Genes related to insulin in diabetics can be silenced and passed on: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030456/Fearful memories carry through at least two generations in mice: https://www.nature.com/news/fearful-memories-haunt-mouse-descendants-1.14272For a review of natural products used as pharmaceuticals, see: https://www.ncbi.nlm.nih.gov/pubmed/26852623

Episode Summary:This episode tackles the polarizing issue of alternative sweeteners and discusses accurate science regarding the concept of toxicity. Topics Discussed are as follows:The sugar crisisWhy are alternative sweeteners attractive?Different alternative sweeteners and their pros/consKey takeaways/summaryDr. Dan's sweetener of choice.Episode References:Average American sugar consumption: http://sugarscience.ucsf.edu/the-growing-concern-of-overconsumption.html#.W_bswi2ZNBwNice comprehensive review on different sweeteners: https://www.sciencedirect.com/science/article/pii/S0278691517303642Drinking too much of anything, even water, can kill: https://www.webmd.com/fitness-exercise/features/water-intoxication#1

Episode Summary:This episode will show why science-based supplementation is essential in today’s complex world due to different lifestyle and environmental factors. Topics discussed are as follows:3 maxims for optimum healthFactors that make supplementation necessaryHow lifestyle and environmental factors degrade human healthSupplementation—bridging the gap Episode References:Poor diet and human mortality: https://www.theguardian.com/society/2017/sep/14/poor-diet-is-a-factor-in-one-in-five-deaths-global-disease-study-reveals Consequences of sleep disruption: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449130/pdf/nss-9-151.pdf Lack of Exercise and chronic disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241367/pdf/nihms-603913.pdf Effects of pollution in chronic illnesses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687917/pdf/mjm12_1p58.pdf Stress and Illness: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341916/pdf/mjms-15-4-009.pdf Mental health crisis in adolescents: https://www.bmj.com/content/361/bmj.k2608 Supplementation with CoQ10 increases CoQ10 intracellular concentration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737275/pdf/BIOF-41-383.pdf Omega-3 fatty acids lower risk of cardiovascular disease—but not cancer: https://www.nejm.org/doi/pdf/10.1056/NEJMoa1811403