Preventive cardiology is undergoing a revolution, with advanced biomarkers and imaging techniques offering unparalleled insights into cardiovascular risk. Traditional risk factors like cholesterol and blood pressure remain important. Still, cutting-edge tools such as Apolipoprotein B (ApoB), Lipoprotein(a) [Lp(a)], high-sensitivity C-reactive protein (hs-CRP), myeloperoxidase (MPO), Lipoprotein-Associated Phospholipase A2 (Lp-PLA2), Carotid Intima-Media Thickness (CIMT), Coronary Calcium Score (CAC), and Coronary Computed Tomography Angiography (CCTA) with Cleerly enable more precise risk assessment and targeted preventive strategies.