He was born around 190 to pagan parents in North Africa. Before baptism he was distinguished in Carthage as a teacher of philosophy and rhetoric. He came to faith in Christ and was baptized at a young age; as soon as he became a Christian he abandoned his prestigious teacher's position, sold his many possessions and gave all his wealth to the poor. He was ordained presbyter in 247, Bishop of Carthage in 248. He was known for his gentleness and paternal care for his flock, combined with firm opposition to heretics. His extensive writings still guide the Church today.

For his confession of Christ, he was beheaded under the Emperor Valerian on September 14; since that is the date of the Exaltation of the Cross, his feast is kept today. At the time of his execution he left twenty-five gold pieces (a huge sum) for the executioner who beheaded him.