Ensaios discutidos: - Initial Vancomycin Taper for the Prevention of Recurrent Clostridioides difficile Infection – TAPER-V | JAMA NetO

- Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism – COBRRA | NEJM

Blogue: https://www.esfoameados.pt/post/janeiro-de-2026-invent%C3%A1rio-do-m%C3%AAs

Lazer do mês

• Filmes "Valor Sentimental" e "Hamnet"
• Peça de teatro "Death of a Salesman" do Arthur Miller

Ensaios discutidos: - Ticagrelor vs Prasugrel in Patients With Diabetes and Multivessel Coronary Artery Disease - TUXEDO2 | JAMA Cardiology

- CYP2D6-Guided Opioid Management and Postoperative Pain Control – ADOPT PGx | JAMA Network Open

Ensaios sinalizados:

- Albumin Replacement Therapy in Septic Shock | JAMA

- Morphine Plus Acetaminophen for Acute Pain in the Emergency Department - PERCEIVE | JAMA Network Open

Blogue: https://www.esfoameados.pt/post/janeiro-de-2026-invent%C3%A1rio-do-m%C3%AAs

Lazer do mês

• Filmes "Valor Sentimental" e "Hamnet"

Ensaios discutidos: - Comparing Oral vs Parenteral Antimicrobial Therapy (COPAT) Trial | CID

-Vernakalant vs procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4) | BMJ

Ensaios sinalizados:

-Withdrawal of HF therapy after AF rhythm control with ejection fraction normalization - WITHDRAW-AF | EHJ

- A Randomized Trial of Tenecteplase in Acute Central Retinal Artery Occlusion

Blogue: https://www.esfoameados.pt/post/janeiro-de-2026-invent%C3%A1rio-do-m%C3%AAs

Outros: Shorter is Better

Recomendações culturais:

• Livro "Malignant" do Vinay Prasad
• Concerto Capitão Fausto no Pavilhão Atlântico (já não dá!...)
• Filmes "Life is beautiful" e "Train Dreams"

ECAs analisados:

• Deferring Arterial Catheterization in Critically Ill Patients with Shock - EVERDAC | NEJM
• Fish‑Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis — PISCES | NEJM
• Medical Management and Revascularization for Asymptomatic Carotid Stenosis — CREST‑2 | NEJM

RS analisada: Reduced‑Dose vs Full‑Dose Direct Oral Anticoagulants for Extended Secondary VTE Prophylaxis in Cancer | AJH Outros: (no blogue) RS:

Tramadol vs placebo for chronic pain: systematic review w/ meta‑analysis & trial sequential analysis | BMJ EBM

Systemic Corticosteroids, Mortality, and Infections in Pneumonia and ARDS | Annals of Internal Medicine

Risk for Cancer With Glucagon-Like Peptide‑1 Receptor Agonists and Dual Agonists | AIM

ECAs:

Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation — DECAF | JAMA

Assessing clinical and cost effectiveness of total vs partial knee replacement (TOPKAT): 10‑years | Lancet Rheum

Minimally Invasive versus Open Pancreatoduodenectomy for Resectable Neoplasms — NEJM Evidence

Personalized Hemodynamic Resuscitation Targeting CRT in Early Septic Shock - ANDROMEDA‑SHOCK‑2 | JAMA

The Mediterranean Diet for Irritable Bowel Syndrome — Annals of Internal Medicine

Carvedilol in Cirrhosis w/ New‑Onset Uncomplicated Ascites Without HighRisk Esophageal Varices - CARVE‑AS | AJG

Rituximab for Relapsing Nephrotic Syndrome in Adults — JAMA

Oral itraconazole vs oral voriconazole for treatment‑naive chronic pulmonary aspergillosis - VICTOR‑CPA | Lancet ID

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury — BICARICU‑2 | JAMA

Preventive care strategy to reduce moderate or severe acute kidney injury after major surgery - BigpAK‑2 | Lancet

Candesartan versus placebo for migraine prevention in episodic migraine — Lancet Neurology

Antithrombotic Therapy after Successful Catheter Ablation for Atrial Fibrillation — OCEAN | NEJM

Recomendações Culturais:

• Livros "Anxious Generation" do Jonathan Haydt e "Heretics" do Chesterton
• Filmes "A wonderful life", "Knives out 3" e "One battle after another" (este mais pelo DiCaprio que pelo filme em si...)
• Concerto 15 anos dos Capitão Fausto no Meo Arena

Artigos em inventário - blogue

Sugestões culturais:

• Música no coração (filme e livro original)
• A Christmas Carol, Charles Dickens (livro sobretudo)
• Maratona Harry Potter (filme e livro)

TEMAS (5 ECAs):

---> ✔ ? ✔ VSR Prefusion F Vaccine for Prevention of Hospitalization in Older Adults - DAN-RSV | NEJM

---> ✔ Rifasutenizol-based triple therapy versus bismuth plus clarithromycin-based triple therapy for first-line treatment of Helicobacter pylori infection in China – EVEREST-HP | The Lancet Infectious Diseases

--> ✔ Methylcobalamin on capecitabine‑induced hand‑foot syndrome in early HER2‑neg breast cancer – MEC-HFS | BMJ

---> ? ? ? Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy - ANGEL-TNK | JAMA

---> ? ? ? Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis – HYPERION | NEJM

---> ✔ Suzetrigine, a Nonopioid NaV1.8 Inhibitor for Treatment of Moderate‑to‑severe Acute Pain – NAVIGATE‑1 & NAVIGATE‑2 | Anesthesiology

---> ✔ Cardiopulmonar POCUS for Hospitalist Management of Undifferentiated Dyspnea | JAMA NO

Inventários:

• Outubro de 2025 - Inventário do mês

TEMAS (6 ECAs e 1 RS de ECAs):

---> Apixaban for Extended Treatment of Provoked Venous Thromboembolism – HI-PRO | NEJM

---> Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke | NEJM

--> Comparison of prophylactic and therapeutic doses of anticoagulation for ACS in sickle cell disease - TASC | AJR-CCM

---> Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction - DIGIT-HF | NEJM

---> Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation - ALONE-AF | JAMA

---> Vericiguat in patients with chronic heart failure and reduced ejection fraction – VICTOR | Lancet

---> Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis | JAMA Internal Medicine

Inventários:

• Julho de 2025

• Agosto de 2025

• Setembro de 2025

Inventário no blogue:

• Junho 25

• Julho 25

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TEMA PRINCIPAL:

Intravenous Tenecteplase before Thrombectomy in Stroke - BRIDGE-TNK | NEJM

» Tenecteplase antes da trombectomia eficaz? E segura? Opiniões divergiram!...e a tua?

TEMAS PRINCIPAIS:

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer - CHALLENGE | NEJM

» Exercício físico com redução de mortalidade equivalente à redução do trastuzumab no carcinoma da mama (HER2+)?

Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes - CONFIDENCE | NEJM

» Finerenona com Empagliflozina em combinação na Nefropatia Diabética? Provavelmente, mas desfecho primário duvidoso (e dúvida crónica sobre o porquê de esquecerem a espironolactona)

Blogue: https://www.esfoameados.pt/post/junho-de-2025-2-o-que-n%C3%A3o-engorda-n%C3%A3o-mata

------------------------------------------- OUTROS ----------------------------------------------------

Junho 25: https://www.esfoameados.pt/post/agosto-de-2024-invent%C3%A1rio-do-m%C3%AAs