From the late 19th to mid 20th centuries, the nation lived in fear of the polio virus. Often handicapping or paralyzing its victims, sometimes resulting in death, the disease was made all the more frightening by the fact that it preyed on young children. Generations of Americans were affected by this incurable illness until a brilliant young medical researcher, empowered by the coordinated efforts of public and private institutions, developed a miraculous vaccine. The expert knowledge and first-hand experiences of Walter Isaacson, David Oshinsky and Geoff Ward, assist Jon Meacham in telling a story which begins with debilitating fear and ends with everlasting hope.