Lionel navigates a "cornucopia" of late-night discourse ranging from the absurd to the deeply personal. Lionel tackles the stigma of mental health, debating whether depression is a "software problem" that requires professional intervention or a personal burden to be respected. Between debunking conspiracy theories about moon landings and dinosaur bones, Lionel explores political decorum, the ethics of the "right to die," and the autonomy of cancer survivors choosing quality of life over grueling treatment. It is an unfiltered look at the "vicissitudes of life" through the eyes of a diverse array of callers.

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