In part two of the HPB Incidentalomas episode, Alexander A. Parikh, MD, Vice Chair of the Hepato-Pancreato-Biliary Disease Site Work Group and disease site work group members Jin He, MD, PhD, and H.J. Kim, MD discuss the incidence, workup, treatment options, and controversies in the management of benign and indolent incidental lesions involving the duodenum and pancreas.