In this episode Dr. Paul Ridker discusses the pivotal role of high-sensitivity C-reactive protein (hsCRP), a biomarker for inflammation, in cardiovascular prevention and treatment. He explains how inflammation and cholesterol together drive atherosclerosis, the significance of hsCRP testing, and the latest clinical trial findings. Dr. Ridker also highlights the importance of primary prevention strategies and the potential of targeted anti-inflammatory therapies to revolutionize cardiovascular care.