Humanities (Audio)

Human cognition and behavior are highly heritable and so is liability to disorders that affect them. This includes neuropsychiatric disorders such as schizophrenia and autism spectrum disorder (ASD). We have started to integrate genetic risk data with the emerging maps of gene regulation to study human specific aspects of gene expression and gene regulation. These analyses indicate that human specific aspects of gene regulation, such as genes regulated by human specific enhancers, are indeed enriched in mutations or common genetic variants that increase risk for ASD and allied neurodevelopmental disorders. This provides evidence that genetic elements underlying human brain evolution are particularly susceptible to disruption in disease. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38299]

Africa is thought to be the ancestral homeland of all modern human populations within the past 300,000 years. It is also a region of tremendous cultural, linguistic, climatic, and genetic diversity. Despite the important role that African populations have played in human history, they remain one of the most underrepresented groups in human genomics studies. A comprehensive knowledge of patterns of variation in African genomes is critical for a deeper understanding of human genomic diversity, the identification of functionally important genetic variation, the genetic basis of adaptation to diverse environments and diets, and the origins of modern humans. We have characterized genomic variation in thousands of ethnically and geographically diverse Africans in order to reconstruct human population history and local adaptation to variable environments and have identified candidate loci that play a role in alcohol metabolism and skin color. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38304]

The first Neandertal DNA was recovered 25 years ago, and since then, ancient DNA has provided many surprising insights into human evolutionary history. Among these are the discoveries of the multiple admixture events among late Pleistocene humans and the remnants of archaic DNA in our own genomes. How does ancient DNA research contribute to the future of anthropogeny? In this talk, I will reflect on the findings of last quarter century of ancient DNA research about archaic humans and their environment as well as examine potential questions that the next quarter century might answer. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38303]

Our species is between 300,000 and 200,000 years old. For most of this one-quarter of a million years, up until just 12,000 years ago, it appears that our ancestors lived in small populations, in small-scale societies of which we can only guess the real nature. We remain in the dark about the age of some of the most diagnostic features of our species: our striding bipedalism, complex tool manufacture and use, fire use, language and societies defining their own identities, collaborating with and competing against neighboring societies. Data from studies of non-human animal behavior remind us of the underappreciated capacities of many other species. However, it has so far not provided evidence for any other species that shares the long list of distinctly human characteristics; chief among those, our species’ capacity to not only simultaneous modify and threaten planetary ecosystems but also document and study such ecosystems across the globe. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38298]

As part of the UC San Diego Libarary Author Talk Series, class of '76 alumnus and two-time Oscar-winning screenwriter and author Rex Pickett talks about his most recent novel, “The Archivist,” a murder mystery that takes a deep dive into the archiving world set in a fictional Geisel Library. Joining Pickett in the discussion are Brian Schottlaender, UCSD University Librarian Emeritus, Caryn Radick, Digital Archivist, Rutgers University, and UCSD's University Librarian Erik Mitchell. Series: "Writers" [Humanities] [Education] [Show ID: 38519]

The discovery and resolution of genetic variation is critical to understanding disease and evolution. Our most recent work sequences diverse human and nonhuman primate genomes using both ultra-long and high-fidelity long-read sequencing technologies. Advances in this area have made possible the first telomere-to-telomere assemblies of the human genome and much more complete chimp, gorilla and orangutan genomes providing new biological insights into regions typically excluded from human genetic and comparative studies. We have discovered mega basepairs of duplicated sequence and/or rapidly evolving sequence present in humans that are absent from other non-human primates. These changes have predisposed our species to recurrent rearrangements associated with disease but also have led to the emergence of new genes important in the expansion of the human frontal cortex of the brain. Our data suggest that large-scale genome structural variation has played and continues to play a crucial role in the evolution of the human species. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 38297]

Explore the politics, economics and art in the time of Frida Kahlo and Diego Rivera. Gregorio Luke, UC San Diego lecturer, author, specialist in Mexican art and culture and former Director of the Museum of Latin American Art, presents a fascinating portrait of Frida Kahlo and Diego Rivera, including their paintings, photographs and rare film footage.

This lecture is part of the San Diego Opera's world premiere of "El último sueño de Frida y Diego" ("The Last Dream of Frida and Diego") by Grammy Award–winning composer Gabriela Lena Frank and Pulitzer Prize–winning librettist Nilo Cruz. Series: "Helen Edison Lecture Series" [Humanities] [Arts and Music] [Show ID: 38454]

Neuroscience has made great strides in the last decade following the Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative, a science and engineering grand challenge that has greatly accelerated research on large-scale recordings from neurons and reconstructions of neural circuits. Large-scale neural network models have in turn inspired major advances in artificial intelligence. These network models have been trained on large-scale data sets to recognize objects in images, caption photographs, and translate text between languages. The most recent advance has been the emergence of pre-trained foundational language models that are self-supervised and can be adapted with fine tuning to a wide range of natural language tasks, each of which previously would have required a separate network model. This is one step closer to the extraordinary versatility of human language. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Education] [Show ID: 38302]

New technologies, shifting demographics and changing societal expectations point to the need for people from all walks of life to be part of fact-based discussions regarding the checks and balances in place when it comes to human research. Anthony Magit, M.D., M.P.H., shares the importance of institutional review boards (IRBs), oversight, and consent when doing research with human subjects. He is joined by Pratheesh Sathyan, Ph.D., and George Hightower, M.D., for a wide-ranging discussion of clinical trials, HIPAA, research design, consumer genetic testing and more. Series: "Exploring Ethics" [Health and Medicine] [Humanities] [Show ID: 38421]

Moderator Mireille Miller-Young joined Diversity in Cannes founder Yolonda Brinkley and filmmaker Wendy Eley Jackson to discuss this important initiative and to celebrate the achievements of global Black women in film. Collectively, they outlined the background and impact of the initiative and strategies for Black women and their allies to create global change. They also reflected on the serious representation gaps in the international film industry and their own experiences breaking barriers. Series: "Carsey-Wolf Center" [Humanities] [Show ID: 38549]