Bruce Trapp and Daniel Ontaneda discuss their retrospective study investigating cortical neuronal loss and cerebral white-matter demyelination in mulitple sclerosis.

Josep Dalmau joins The Lancet Neurology to discuss recognition and outcomes of autoimmune encephalitis after herpes simplex encephalitis.

David Eidelberg and Katharina Schindelbeck join The Lancet Neurology to explain their new review of the applications of network imaging biomarkers in Parkinson's disease.

Eugene Major and David Clifford join The Lancet Neurology to discuss their review of pathogenesis and treatments for progressive multifocal leukoencephalopathy.

Torbjörn Tomson discusses the issue of antiepileptic drugs during pregnancy and the risk of major congenital malformations.

Christian Elger discusses the diagnostic challenges in epilepsy with the detection and reporting of seizures.

Jeffrey Cohen joins us to talk about the process of updating and revising the McDonald criteria for diagnosis of MS.

Jose Bras discusses his study of the genetic architecture of dementia with Lewy bodies.

Andrew Maas and David Menon, lead authors, discuss The Lancet Neurology Commission on traumatic brain injury and outline the worldwide burden.

Keith Josephs talks about considering TDP-43 as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease.