eanCast: Weekly Neurology

Moderator: Luca Sebastianelli (Vipiteno, Italy)

Guest: Geir Andre Ringstad (Oslo, Norway)

In this episode, Luca Sebastianelli speaks with Geir Andre Ringstad about the glymphatic system and its relevance to neurological practice. They discuss brain fluid transport and molecular clearance, with a focus on traumatic brain injury, sleep, diagnostic approaches, and the challenges of translating experimental findings into clinically relevant measures of individual CSF clearance.

Moderator: Mariusz Siemiński (Gdansk, Poland)

Guest: David Schreier (Bern, Switzerland)

In this episode, Mariusz Siemiński speaks with David Schreier about the relationship between sleep disorders and traumatic brain injury. They discuss sleep disorders as potential risk factors for injury, common sleep disturbances following traumatic brain injury, and the diagnostic and clinical importance of recognising sleep-wake disturbances in neurological practice.

Moderator: Luca Cuffaro (Agrigento, Italy)

Guest: Ingibjörg Jónsdóttir (Reykjavík, Iceland)

In this episode, Luca Cuffaro speaks with Ingibjörg Jónsdóttir about burnout and the neurobiology of stress-related exhaustion. They discuss the clinical features of burnout, the limitations of biological markers such as cortisol, early warning signs including impaired recovery and sleep disturbances, and the importance of recognising work-related stressors in neurological and healthcare practice.

Moderator: Lorenzo Barba (Halle Saale, Germany)

Guest: Henrik Zetterberg (Gothenburg, Sweden) and Gemma Salvadó (Barcelona, Spain)

In this episode, Lorenzo Barba speaks with Henrik Zetterberg and Gemma Salvadó about the role of biomarkers in translational neurology and monitoring therapeutic efficacy. They discuss the clinical application of fluid biomarkers, particularly plasma phosphorylated tau, key diagnostic considerations, and the emerging need for biomarkers of tau pathology, co-pathologies, and treatment response in neurological practice.

Moderator: Harald Prüß (Berlin, Germany)

Guest: Juna de Vries (Rotterdam, Netherlands)

In this episode, Harald Prüß speaks with Juna de Vries about targeted cellular therapy for anti-NMDA receptor encephalitis. They discuss key diagnostic features, current immunotherapies, and emerging approaches including CAR T-cell therapy and antibody-selective treatments, with a focus on outcome measures, prognostic assessment, early diagnosis, and their relevance to neurological practice.

Moderator: Kleopas Kleopa (Nicosia, Cyprus)

Guest: Jo Ng (London, UK)

In this episode, Kleopas Kleopa speaks with Jo Ng about gene therapy for rare neurological disorders. They discuss the clinical potential of AAV-based therapies, key diagnostic and therapeutic considerations including early diagnosis and treatment timing, and challenges related to safety, immune responses, dosing, and long-term outcomes, with a focus on translating advances into neurological practice.

Moderator: Kristian Steen Frederiksen (Copenhagen, Denmark)

Guest: Katarina Rukavina (Berlin, Germany)

In this episode, Kristian Steen Frederiksen speaks with Katarina Rukavina about guideline implementation in neurological practice. They discuss factors influencing adherence to EAN guidelines, the importance of integrating implementation from the start of guideline development, stakeholder and national society engagement, and the potential role of AI in improving access to evidence-based recommendations.

Moderator: Alessandra Fanciulli (Innsbruck, Austria)

Guest: Jalesh N. Panicker (London, UK) and Mario Habek (Zagreb, Croatia)

In this episode, Alessandra Fanciulli speaks with Jalesh N. Panicker and Mario Habek about the assessment and management of neurogenic urinary and sexual symptoms. They discuss the clinical recognition of urogenital dysfunction in neurological diseases, practical approaches to initial assessment and treatment, and the role of interdisciplinary care in improving neurological practice.

Moderator: Piergiorgio Lochner (Homburg, Germany)

Guest: Stephan Schreiber (Berlin, Germany)

In this episode, Piergiorgio Lochner speaks with Stephan Schreiber about carpal tunnel syndrome and its detection by ultrasound. They discuss key clinical and electrophysiological findings, ultrasound assessment of median nerve structure, and the recognition of anatomical or systemic red flags, highlighting the role of nerve ultrasound in diagnosis and neurological practice.

Moderator: Piergiorgio Lochner (Homburg, Germany)

Guest: Arijana Lovrečić-Huzjan (Zagreb, Croatia)

In this episode, Piergiorgio Lochner speaks with Arijana Lovrečić-Huzjan about giant cell arteritis and its neurological presentation. They discuss key clinical features, inflammatory markers, and the role of vascular ultrasound in diagnosis, with emphasis on early recognition, differential diagnosis, and timely treatment to prevent visual and cerebrovascular complications.