Moderator: Cláudia Santos Silva (Lisbon, Portugal)

Guest: Andrea Calvo (Turin, Italy)

In this episode, Cláudia Santos Silva speaks with Andrea Calvo about the genetics of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). They discuss the shared genetic basis of these disorders, key disease-associated genes, and the role of genetic testing, counselling, and result interpretation in clinical practice, highlighting how genetic discoveries are advancing precision medicine and emerging gene-targeted therapies in ALS and FTD.

Moderator: Raffaele Dubbioso (Naples, Italy)

Guest: Andrea Malaspina (London, UK) and Francesco Di Lorenzo (Rome, Italy)

In this episode, Raffaele Dubbioso speaks with Andrea Malaspina and Francesco Di Lorenzo about the growing role of neurofilaments as biomarkers in amyotrophic lateral sclerosis and frontotemporal dementia. They discuss the biological basis and clinical interpretation of neurofilament measurements, their diagnostic and prognostic value, and their emerging role in identifying pre-symptomatic disease, monitoring progression, and supporting clinical trials in neurological practice.

Moderator: Elisa Canu (Milan, Italy)

Guest: Anna Gilioli (Milan, Italy)

In this episode, Elisa Canu speaks with Anna Gilioli about social cognition impairment in amyotrophic lateral sclerosis (ALS). They discuss its clinical manifestations, underlying neurobiological mechanisms, and assessment approaches, highlighting the importance of early recognition and its implications for patient management, prognosis, and multidisciplinary neurological care.

Moderator: Valentina Iuzzolino (Naples, Italy)

Guest: Elka Stefanova (Belgrade, Serbia) and Mamede de Carvalho (Lisbon, Porugal)

In this episode, Valentina Iuzzolino speaks with Elka Stefanova and Mamede de Carvalho about diagnostic challenges in amyotrophic lateral sclerosis and frontotemporal dementia. They discuss clinical heterogeneity, key differential diagnoses and red flags, the role of Gold Coast criteria and neurophysiology in ALS, and the importance of longitudinal clinical assessment and neuroimaging in distinguishing frontotemporal dementia from primary psychiatric disorders.

Moderator: Raphael Wurm (Vienna, Austria)

Guest: Roland Wiest (Bern, Switzerland)

In this episode, Raphael Wurm speaks with Roland Wiest about how the AI revolution is set to reshape the clinical environment in neurology. They discuss the areas where augmentation and automation are likely to have the greatest impact, including neuroimaging, clinical workflows, and decision support, while exploring how neurologists can prepare themselves and their institutions to translate emerging AI technologies into meaningful improvements for both clinicians and patients.

Moderator: Georg Starke (Munich, Germany)

Guest: Giulia Di Rauso (New York, USA)

In this episode, Georg Starke speaks with Giulia Di Rauso about trustworthiness and the use of artificial intelligence in neurological research and clinical practice. They discuss explainability, data quality, interpretability, and human oversight in AI systems, highlighting key considerations for responsible integration of AI tools into neurology and the importance of maintaining clinical judgement.

Moderator: Maria Chiara Malaguti (Rovereto, Italy)

Guest: Gary Leeming (Liverpool, UK)

In this episode, Maria Chiara Malaguti and Gary Leeming discuss the evolving role of artificial intelligence in neurology. Aimed at clinical neurologists, the conversation explores how AI may support clinical practice, while also addressing its limitations, ethical implications, and the need for human oversight. As AI becomes increasingly embedded in healthcare, neurologists will need to develop a solid understanding of these tools in order to use them critically, guide their implementation, and remain in control of clinical decision-making.

Moderator: Raphael Bernard-Valnet (Lausanne, Switzerland)

Guest: Roland Wiest (Bern, Switzerland) and Monica Moroni (Trento, Italy)

In this episode, Raphael Bernard-Valnet speaks with Roland Wiest and Monica Moroni about the fundamentals of artificial intelligence in clinical neurology and its practical implications for neurologists. They discuss key applications such as imaging analysis, diagnostic and decision-support tools, and emerging use in wearables, while addressing interpretability, standardisation, and current barriers to routine clinical implementation.

Moderator: Kirsten R. Müller-Vahl (Hanover, Germany)

Guest: Natalia Szejko (Warsaw, Poland) and Anna Dunalska (Warsaw, Poland)

In this episode, Kirsten R. Müller-Vahl speaks with Natalia Szejko and Anna Dunalska about functional neurological disorders and the influence of social media. They discuss common clinical presentations, challenges in diagnosis based on positive signs, and the impact of online information on symptom expression, patient expectations, and clinical management, with implications for contemporary neurological practice.

Moderator: Selma Aybek (Fribourg, Switzerland)

Guests: Gabriela Gilmour (Calgary, Canada) and Katarzyna Śmiłowska (Sosnowiec, Poland)

In this episode, Selma Aybek speaks with Gabriela Gilmour and Katarzyna Śmiłowska about the overlap between functional neurological disorders and movement disorders. They discuss key diagnostic principles based on positive clinical signs, mechanisms underlying co-occurrence, and practical challenges in distinguishing functional symptoms from conditions such as Parkinson’s disease, with implications for accurate diagnosis and management in neurological practice.