In this episode of Take as Directed, J. Stephen Morrison speaks with Dr. Trevor Mundel, President of the Global Health Division at the Bill & Melinda Gates Foundation. They discuss the arc of Dr. Mundel’s personal career and his remarkable tenure at the Gates Foundation, including the creation of the Medical Research Institute; the launch of CHAMPS, the Child Health and Mortality Prevention Service; and the establishment of CEPI, the Coalition for Epidemic Preparedness Innovations. In closing, they discuss the issues that give him the greatest concern, and the reasons he is hopeful looking to the future.