Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) represents one of the most complex and physiologically demanding procedures encountered in modern perioperative medicine.

In this episode of Anesthesia Alchemy: Lynn & Garry Unplugged, Garry takes listeners on a deep dive into the anesthetic management of these challenging cases. Rather than a checklist approach, this conversation walks through how to think during a HIPEC case—understanding the phases, recognizing evolving physiology, and staying ahead of rapid changes.

Here’s some of what you’ll hear in this episode:

🔥 HIPEC creates controlled physiologic stress

🧠 Anticipation matters more than reaction

💧 Precision fluid management is critical

🌡️ Temperature swings must be managed actively

🔄 Physiology is constantly evolving

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